UNLABELLED Obstructive sleep apnea (OSA) commonly coexists with epilepsy, and treatment of OSA may decrease seizure frequency. However, it is unclear whether patients with medically refractory epilepsy have a higher incidence of OSA compared with well-controlled epilepsy patients and whether the two groups carry different risk factors. PURPOSE This study aimed to investigate the presence of O...

Background: Sleep Seizures (SSs) generally occur in refractory focal epilepsy, but their detailed characteristics and circadian patterns are still controversial. The effect of SSs on epilepsy surgery outcome has been addressed in few studies without definitive prognostic value.   Objectives: This study investigated the characteristics of SSs and their prognosis in refractory focal epilepsy. M...

M. Dezortova, M. Hajek, P. Krsek, F. Jiru, A. Skoch, J. Zamecnik, P. Marusic, M. Kyncl, M. Tichy, V. Komarek MR-Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Dept Pediatric Neurology, Faculty Hospital Motol, Prague, Czech Republic, Dept Pathology and Molecular Medicine, Faculty Hospital Motol, Prague, Czech Republic, Dept Neurology, Faculty Hospital Motol, Prag...

pet (positron emission tomography) is a powerful imaging technique that can provide quantitative information on the distribution of positron emitter labeled radiopharmaceuticals (pet radiopharmaceuticals) in the body. positrons (ß+) are positively charged beta particles. they are emitted when the atom is proton rich. a positron has only a transient existence. after losing all of its kinetic ene...

Introduction Biotinidase deficiency is a life threatening inborn error of metabolism specially when delayed in diagnosis. We report a 2-month-old male infant that presented with refractory infantile spasm, alopecia and seborrheic dermatitis. With a high suspicion of the biotinidase deficiency we started biotin 10 mg daily orally before definite diagnosis was made. Rapid treatment was life-savin...

bangladesh is one of the smaller states in asia. but it has a long and rich history of nuclear medicine for over sixty years. the progress in science and technology is always challenging in a developing country. in 1958, work for the first nuclear medicine facility was commenced in dhaka in a tin-shed known as ‘radioisotope centre’ and was officially inaugurated in 1962. since the late 50s of t...

Background:epilepsy is one of the common neurological disorders and approximately 0.5-1% of populations suffers from it. Unfortunately, despite of treatment by antiepileptic drugs, between 20-30% of patients cannot be controlled completely. There are a lot of supplementary therapies for this group of patients and in this study, L-arginine was used as an additional therapy...

introduction biotinidase deficiency is a life threatening inborn error of metabolism specially when delayed in diagnosis. we report a 2-month-old male infant that presented with refractory infantile spasm, alopecia and seborrheic dermatitis. with a high suspicion of the biotinidase deficiency we started biotin 10 mg daily orally before definite diagnosis was made. rapid treatment was life-savin...

There are overwhelming data supporting the inflammatory origin of some epilepsies (e.g., Rasmussen's encephalitis and limbic encephalitis). Inflammatory epilepsies with an autoimmune component are characterized by autoantibodies against membrane-bound, intracellular or secreted proteins (e.g., voltage gated potassium channels). Comparably, little is known regarding autoantibodies targeting nucl...