Background The nucleated red blood cells (NRBCs) are a readily available hematological parameter with potential for risk stratification mortality. Therefore, our objective was to assess the predictive significance of NRBCs ICU mortality among ST-elevation myocardial infarction (STEMI) patients admitted an ICU. Additionally, we aimed compare capacity that acute physiology and chronic health eval...

During malaria blood-stage infections, Plasmodium parasites interact with the RBC surface to enable invasion followed by intracellular proliferation. Critical factors involved in invasion have been identified using biochemical and genetic approaches including specific knockdowns of genes of interest from primary CD34+ hematopoietic stem cells (cRBCs). Here we report the development of a robust ...

A child diagnosed in utero with hydrops fetalis and a hematocrit of 6.4% was studied to determine the etiology of the anemia. Fetal red blood cells (RBCs) obtained during in utero transfusion had extremely abnormal osmotic fragility. A maternal history of mild autosomal dominant hereditary spherocytosis was present, and the father, who was hematologically normal, had a slightly abnormal osmotic...

Leucocytozoon parasites infect a large number of avian hosts, including domestic chicken, and cause significant economical loss to the poultry industry. Although the transmission stages of the parasites were observed in avian blood cells more than a century ago, the specific host cell type(s) that the gametocytes infect remain uncertain. Because all the avian blood cells, including red blood ce...

Haematology The mean cell volume (MCV) indicates the average size of red blood cells (RBCs). Regenerative anaemias are usually macrocytic because reticulocytes have high MCVs. However, macrocytosis is not just a feature of regenerative anaemias since non-regenerative anaemias associated with FeLV infection or myelodysplasia can be associated with macrocytosis (Shimoda, et al 2000, Weiss 2006b)....

In a rat model of chronic mountain sickness, the excessive polycythemic response to hypoxic exposure is associated with profound splenic erythropoiesis. We studied the uptake and distribution of radioactive iron and red blood cell (RBC) morphology in intact and splenectomized rats over a 30-day hypoxic exposure. Retention of (59)Fe in the plasma was correlated with (59)Fe uptake by both spleen ...

Background: The incidence of chronic liver disease is increasing worldwide. Common causes include alcohol, hepatitis B and C non-alcoholic fatty (NAFLD). Abnormalities in hematological parameters are common patients with cirrhosis. There paucity data geriatric population diseases.Methods: A pre-structured performa was prepared to collect the demographic that included Age, Gender, Occupation, Ar...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 77-year-old man visited our hospital complaining of fever, excessive sputum production, and dyspnea. immature plasma cells (plasmablasts), accounting for 58% of the leukocytes, and marked rouleaux formation (A). Interestingly, rouleaux formation of the neo...

We evaluated the new UniCel DxH 800 hematology analyzer (Beckman Coulter, Miami, FL) vs the Cell-Dyn Sapphire (Abbott Diagnostics, Santa Clara, CA) using 156 pediatric specimens in Microtainer tubes (Becton Dickinson, Franklin Lakes, NJ). The CBC and differential showed good interinstrument correlation, including WBCs (r = 0.995), RBCs (r = 0.992), hemoglobin (r = 0.998), mean corpuscular volum...

We examined the effects of varying incubation conditions on the in vitro activity of 4-hydroperoxycyclophosphamide (4HC). 4HC activity against CFU-GM and against the K562 tumor cell line decreased with increasing the RBC concentration of the incubation mixture. Increasing the concentration of nucleated bone marrow cells in the incubation mixture also decreased the 4HC activity. Evaluation of 53...