The aim of this work was to coat pH-sensitive microneedle arrays with inactivated polio vaccine (IPV) particles and N-trimethyl chitosan chloride (TMC) via electrostatic interactions, and assess the immunogenicity of the vaccine after topical application of the coated microneedles in rats. The surface of 200 μm long microneedles was first chemically modified with pH-sensitive (pyridine) groups ...

Chitosan and randomly methylated β-cyclodextrin were the most to be studied absorption enhancers for nasal administration recently. The enhancing absorption mechanisms of each other were different. Authors chosen estradiol as the model drug used in situ and in vivo methods to study whether or not they could combine to enhance the nasal absorption. In situ study data indicated that the optimal c...

lysine metabolism has been measured in rats fed a diet low in trimethyl-lysine and carnitine (Davis & Hoppel, 1983, 1986). Under these steady-state conditions, the total body trimethyl-lysine content is similar to the total body carnitine content. The tissue distribution of peptide-linked and free trimethyl-lysine shows that approximately 68% of the total trimethyl-lysine is present in skeletal...

OBJECTIVE The study objectives were to assess the efficacy of N,O carboxymethyl chitosan film in reducing postsurgical adhesion in a rabbit cardiac injury model and to confirm the efficacy of N,O carboxymethyl chitosan gel and film in reducing postsurgical adhesion formation in a pig cardiac injury model. METHODS (1) Rabbit cardiac injury model: Cardiac injury was generated by abrading the an...

We report a facile route for the green synthesis of trimethyl chitosan nitrate-capped silver nanoparticles (TMCN-AgNPs) with positive surface charge. In this synthesis, silver nitrate, glucose, and trimethyl chitosan nitrate (TMCN) were used as silver precursor, reducing agent, and stabilizer, respectively. The reaction was carried out in a stirred basic aqueous medium at room temperature witho...

The effect of partial autolysis during storage of shrimp biowaste on the quality of the extracted chitin and chitosan has been investigated. Shrimp waste materials were stored in a 30 o C incubator for 1-4 days. The quality of the chitin and chitosan extracted from these materials was assessed by ash and protein analysis and in solution by viscosimetry. Chitosan from fresh biowaste, treated for...

Herein the extraction method of fucoidan from Laminaria japonica is reported. Firstly, chitosan, chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (HACC), and hexadecyltrimethylammonium bromide (CPAB) were used to extract the fucoidan. The results showed that chitosan was the optimal extractant compared with the other two extractants. After extraction, different aqueous solutions, includin...

Introduction: This study was conducted to evaluate the influence of chitosan Nano-gel/emulsion coating functionalized by Ziziphora clinopodioides essential oil (ZCEO) and nisin on growth inhibition of Escherichia coli O157: H7 inoculated in beef samples during 16 days in cold storage condition (4˚C). Methods: Beef sample ...

The conjugates of some kinds of anticancer agents with chitin and chitosan derivatives display good anticancer effects with a decrease in the adverse effects of the original drug due to a predominant distribution into the cancer and a gradual release of free drug from the conjugates. For instance, doxifluridine and 1-beta-D-arabinofuranosylcytosine (Ara-C) were conjugated with chitosan via glut...