Sebaceous carcinoma (SC) is a highly aggressive malignant adnexal tumor of sebaceous gland origin, accounting for less than 1% of cutaneous. Extraocular sebaceous carcinomas are more aggressive than their ocular counterpart with a predilection for the skin of head and neck, trunk, salivary glands and extremities in decreasing order of frequency. Rippled effect literally means "gradually spreadi...

Fas ligand (FasL) can be either membrane bound, or cleaved by metalloproteinases (MMP) to produce a soluble protein. The two different forms of FasL are reported to have opposite functions-membrane-bound FasL (mFasL) is proinflammatory and soluble FasL (sFasL) is antiinflammatory. We previously showed that, within the immune-privileged eye, tumors expressing high levels of mFasL overcame the su...

BACKGROUND AND PURPOSE To report outcomes and toxicity after proton beam radiotherapy for non-peripapillary choroidal and ciliary body melanoma considered unsuitable for other eye-sparing therapies. MATERIALS AND METHODS An existing database of 77 patients with non-peripapillary tumors treated at TRIUMF, Canada, including patient, tumor, and treatment characteristics, was updated with ocular ...

Ocular melanoma has been treated using proton therapy at the Centre Antoine Lacassagne (CAL) since 1991, following commissioning of 65 MeV cyclotron MEDICYC and its associated beam-lines a few years earlier. The dedicated eye-line is optimized for shallow tumors sharp penumbrae provides state-of-the-art quality care. cyclotron, treatment systems, which are maintained exclusively by staff CAL, h...

  Background and Objective: The frequency and pattern of eye neoplasms differ in various geographic areas. Our aim was to determine the distribution of patient age, gender, ocular tumor origin, location and histological type in our region. Materials and Methods: In this cross-sectional study, all of the 384 eye globe enucleation cases carried out during a 10-year period in Farabi Medical Cent...

1. Shields JA, Shields CL, Ehya H, Eagle RC, De Potter P. Fine-needle aspiration biopsy of suspected intraocular tumors: the 1992 Urwick Lecture. Ophthalmology. 1993;100: 1677-1684. 2. Collaborative Ocular Melanoma Study Group. Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study: COMS report No. 1. Arch Ophthalmol. 1990;108:1268-1273. 3. Schyberg E. Fine need...

background: tumors involving the hand skeleton are rare. however, a basic knowledge of hand tumors is necessary for every clinician. this is due to the importance of distinguishing typical benign tumors from life or limb threatening malignant ones. methods: this study is a review of 99 cases of osseous hand tumors presented to the department of orthopedic surgery, imam khomeini hospital in tehr...

Silicone sponges were sutured to the sclera of owl monkeys to create an indentation which would simulate a tumor of the posterior segment of the eye. A tantalum clip inserted in the silicone sponge served as a marker for radiographic localization of the simulated tumors. The acute lesions obtained on the retina and choroid after moderately high doses of proton irradiation suggest that this meth...

The occurrence of vascular basophilia in ocular tumors has been a selective histologic feature of retinoblastomas. We recently observed a metastatic oat-cell carcinoma to the choroid which also demonstrated such a vascular hematoxyphilia. Histologic review of a variety of ocular and orbital metastatic carcinomas failed to yield a similar basophilic pattern. Examination of 100 consecutive retino...