We read with great interest the article by Kohno et at published in the December, 1992, issue of Chest concerning the comparison of ofloxacin and ethambutol in the treatment of pulmonary beos’ We wish to supplement and reiterate on several issues concerning the potential role of ofloxacin for the treatment of pulmonary tuberculosis. As referenced by the authors, ofloxacin has distinct activity ...

Objective: To study the pharmacokinetics of ofloxacin using salivary drug concentration when administered alone or in combination with rifampicin (R), isoniazid (H) and pyrazinamide (Z) and also to assess the saliva to plasma concentration ratio. Material and Methods: Twelve healthy male volunteers were investigated on four different occasions with an interval of at least one week between occas...

OBJECTIVE To determine the safety and efficacy of ofloxacin otic solution in the treatment of acute otorrhea in children with tympanostomy tubes. DESIGN Multicenter study with an open-label, prospective ofloxacin arm and retrospective historical and current practice arms. SETTING Ear, nose, and throat pediatric and general practice clinics and office-based practices. SUBJECTS Children you...

Background: Although the use of the antimicrobial, trimethoprim-sulfamethoxazole, in combination with the antisecretory and antimotility agent, loperamide, has been shown to be efficacious in the treatment of traveler's diarrhea, the use of fluoroquinolone antimicrobials in combination with loperamide has less support in the literature. The present study was designed to compare the efficacy of ...

PURPOSE To determine whether corneal epithelial healing differs after the use of topical ciprofloxacin alone, topical ofloxacin alone, or topical ofloxacin with artificial tears in patients having photorefractive keratectomy (PRK). SETTING Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston, Houston, Texas, USA. METHODS Eighteen patients ...

The in-vitro activity of levofloxacin was compared with ofloxacin and D-ofloxacin against 130 isolates of Staphylococcus aureaus and 117 isolates of coagulase-negative staphylococci, using the agar dilution method. In general, levofloxacin was equally active or up to fourfold more active than ofloxacin against all staphylococci, including 61 methicillin-resistant S. aureus. In contrast, D-oflox...

The in vitro activities of ofloxacin alone and in combination with metronidazole against 177 anaerobic bacteria isolated from intra-abdominal infections, as determined by broth microdilution, showed that some Bacteroides fragilis strains were susceptible and that most other B. fragilis group species strains were resistant to ofloxacin. Isolates of other anaerobic species and genera, including t...

The in vitro activity of rac-mefloquine hydrochloride and its pure enantiomers was tested against a chloroquine-resistant (PF.IBS2) strain of Plasmodium falciparum. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic mefloquine or its enantiomers over the concentration range of 10-9 to 10-4 M. ...

stereoselectivity of mefloquine enantiomers were studied in rats after oral administration of a single 50mg/kg dose of the racemate. pharmacokinetic parameters of (+)-(rs)-mfq in blood and plasma showed no significant difference. the concentration, auc , clif and vdlf of (+)-(rs)-enantiomerin blood were significantly higher than those for the (-)-(sr)-enantiomer. tlie results obtained from this...

INTRODUCTION To report a case of ofloxacin-associated leucopoenia, which occurred in a patient of falciparum malaria shortly after administration and resolved following discontinuation of the drug. CASE PRESENTATION A 44 year old female was admitted in circulatory shock with a diagnosis of falciparum malaria, suffering from fever, diarrhoea and vomiting. After successful resuscitation she was...