نتایج جستجو برای: oncogene protein
تعداد نتایج: 1251152 فیلتر نتایج به سال:
We have previously described the inhibition of glucocorticoid-dependent transcription from the mouse mammary tumor virus long terminal repeat promoter by products of the H-ras and v-mos oncogenes. We have studied the effects of conditional oncogenes on expression of glucocorticoid-dependent indicator genes. Expression of the glucocorticoid-dependent transcription of the tyrosine aminotransferas...
Frequent gains of chromosome 20q12-13 in ovarian tumors indicate that at least one important oncogene is found at that locus. One of the genes there is EEF1A2, which maps to 20q13.3 and encodes protein elongation factor eEF1A2. This review will focus on recent evidence indicating that EEF1A2 is an important ovarian oncogene and that the protein elongation network can activate tumorigenesis and ...
AIM Since interactome analysis of diseases can provide candidate biomarker panel related to the diseases, in this research, protein-protein interaction (PPI) network analysis is used to introduce the involved crucial proteins in Gastric adenocarcinoma (GA). BACKGROUND Gastric adenocarcinoma (GA) is the most common type of stomach cancer. There is no efficient diagnostic molecular method for G...
MYB (v-MYB avian myeloblastosis viral oncogene homolog) transcription factor (TF) family has numerous members with complex and diverse functions, which perform an integral role in regulating the plant’s response to adversity. This study used cloning obtain a novel TF gene from diploid strawberry Fragaria vesca, was given designation FvMYB44. Subcellular localization results showed that protein ...
Spitz nevus (SN) is predominantly distributed throughout the lower extremities, while an acral location rare. Since SN occasionally resembles clinicopathological presentation of malignant melanoma (MM), it presents a diagnostic challenge, especially on glabrous skin. Past reports suggest that several genetic aberrations are associated with specific subtypes melanocytic tumors. Immunohistochemis...
Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β-catenin, Myc, c-Jun, and the Notch intracellular-domain (N-ICD) protein. RNF4 enhances the transcriptional activity of these factors, as well as ...
Alzheimer's disease (AD) is a degenerative brain with complex clinical manifestations and pathogeneses such as abnormal deposition of beta-amyloid protein inflammation caused by the excessive activation microglia. CXC motif chemokine receptor type 4 (CXCR4) G protein-coupled that binds to ligand 12 (CXCL12) activate downstream signaling pathways, Janus kinase/signal transducer activator transcr...
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