Colorectal cancer is a leading cause of cancer incidence and death. Therapies for those with unresectable or recurrent disease are not considered curative at present. More effective and less toxic therapies are desperately needed. Historically, the immune system was thought to be an enemy to oncolytic viral therapy. Thinking that oncolysis would be the only mechanism for cell death, oncolytic v...

Primary and metastatic neoplasms of the liver account for more than a million deaths per year worldwide. Despite decades of research, effective novel therapies for these cancers are urgently needed. Oncolytic virotherapeutics represent a novel class of pharmacophore that holds promise for the treatment of hepatic neoplasms. Cancer-specific replication is followed by oncolysis, virus spreading a...

of disciplines were represented including anthropology, psychology, psychiatry, neurology, mathematics, linguistics, and zoology. One of the major topics was the complexity and variability of primate societies which depend on factors such as the breeding season, estrus cycles, and formation of new groups. Another theme was the evolutionary trend in the naturalistic and biological approaches. An...

The fact that many viruses will propagate in, and some will damage, tumor tissue has been demonstrated by many investigators using many experimental systems. Oncotropism and oncolysis have also been studied in clinical experiments. The literature through 1953 has been reviewed by Moore (5). More recent clinical studies include the systemic administration of certain arthropodborne viruses1 and a...

Abstract :  Reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  The efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  Cells expressing ac...

Despite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis. Recent findings suggest a mechanism by which natural killer cells limit the efficacy of oncolytic viruses via natural cytotoxicity receptors.