blood pressure rises rapidly upon awakening and maybe responsible, in part, for the increased incidence of myocardial infarction and stroke during the morning hours. the aim of the present study was, therefore, to develop a novel chronotherapeutic formulation of metoprolol tartrate (mt) for night time dosing providing maximum effect in the morning hours. core tablets contained mt, sodium chlori...

Cyclic ADP-ribose (cADPr) has been shown to release intracellular Ca2+ from sea urchin eggs and a variety of vertebrate cell types, although its mechanism of action remains elusive. We employed the caged version of cADPr to study the [Ca2+] transient kinetics in intact sea urchin eggs for insights into how cADPr gates Ca2+ release. Ca2+ release triggered by photolytic production of cADPr was in...

Extended release (XR) formulation of levetiracetam (LEV) is approved by the Food and Drug Administration as an add-on to other antiepileptic drugs (AEDs) for adults with partial onset seizures. This is based on class-I evidence demonstrating significant seizure reduction in once daily dosing. Keppra-XR is marketed with the brand name of Keppra XR since 2008 (UCB Pharma). Its original immediate ...

An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the LHRH neurosecretory system is already active during the neonatal period but subsequently enters a dormant state in the juvenile/prepubertal period. Neither gonadal steroid hormones nor the absence of facilitato...

Cyclic ADP-ribose (cADPr) has been shown to release intracellular Ca from sea urchin eggs and a variety of vertebrate cell types, although its mechanism of action remains elusive. We employed the caged version of cADPr to study the [Ca] transient kinetics in intact sea urchin eggs for insights into how cADPr gates Ca release. Ca release triggered by photolytic production of cADPr was initially ...

The early morning routine before school can be a particularly challenging time for children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Morning-dosed stimulants often fail to adequately address ADHD symptoms impaired functioning, due the delay in their onset of effect, which has significant impact on entire family. Clinicians should consider treatments that are effecti...

AbstractBackground: Around the world, one of the main concerns and risky behaviors among youths ismethamphetamine consumption. Since the age of onset of methamphetamine use is decreasing, therefore, itis important to identify the effective factors on the age of onset of methamphetamine consumption. In the<sp...

the present study is aimed at the overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of cisplatin. nanocapsules of cisplatin containing ethylcellulose have been prepared using solvent evaporation technique under ambient conditions. the prepared nanocapsules were used for controlled drug release of anticancer agents with gold and iron oxide nanoparticles. ...