In recent years, researchers have found that adiponectin (ANP) plays an important role in the pathogenesis of Alzheimer's disease (AD), and low serum concentrations of ANP are associated with AD. Higher plasma ANP level have a protective effect against the development of cognitive decline, suggesting that ANP may affect AD onset. Meanwhile, accumulating evidence supports the crucial role of ANP...

STUDY DESIGN A randomized controlled trial. OBJECTIVE To investigate feed-forward activation or timing of abdominal muscle activation in response to rapid shoulder flexion after 8 weeks with core stability exercises, sling exercises, or general exercises in chronic nonspecific low back pain (LBP) patients. SUMMARY OF BACKGROUND DATA Delayed onset in abdominal muscles has been associated wit...

experiments were carried out to observe the influence of loading type on concrete beam specimens. beam specimens made of similar concrete mixture with the same geometry were tested under three point static loading and low velocity drop weight impact loading. load – displacement behavior, absorbed energy dissipation capacity, stiffnesses, failure modes of beam specimens were obtained and discuss...

Although a portion of risk for late-onset AD (LOAD) is attributable to APOE, the search for other loci is ongoing. The authors hypothesize that psychotic symptoms with LOAD (LOAD+P) identify a potentially more etiologically homogeneous form of AD. Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of gr...

OBJECTIVE The aim of this study was to investigate whether the extent and topography of cerebral demyelination correlates with and predicts disease progression in patients with juvenile metachromatic leukodystrophy (MLD). METHODS A total of 137 MRIs of 46 patients with juvenile MLD were analyzed. Demyelination load and brain volume were quantified using the previously developed Software "clus...

BACKGROUND/AIMS Whether age at onset influences functional deterioration in Alzheimer disease (AD) is unclear. We, therefore, investigated risk factors for progression in activities of daily living (ADL) and nursing home placement (NHP) in cholinesterase inhibitor (ChEI)-treated patients with early-onset AD (EOAD) versus late-onset AD (LOAD). METHODS This 3-year, prospective, observational, m...

Background: The heralding of baby boomers and a subsequent surge in elderly population, has led to immense research in unravelling the mysteries in the geriatric age group with Alzheimer’s disease (AD). Alzheimer’s disease (AD) is a neurodegenerative disorder with varied cognitive dysfunctions. However no comprehensive study has been carried out in South East Asia(Kashmir, India) to investigate...

To alleviate the high cost of main-memory accesses, computer architects have proposed various speculation mechanisms, including load-value prediction. A load-value predictor guesses the result of load instructions, thus allowing dependent instructions to execute without having to wait for the memory access to complete. Unfortunately, costly mispredictions hinder the true potential of load-value...

Plasma Abeta42 (amyloid beta42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta42, we used plasma Abeta42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with ...