Cardiac sodium channels are integral membrane proteins whose structure is not known at atomic level yet and their molecular kinetics is still being studied through mathematical modeling. This study has focused on adapting an existing model of cardiac Na channel to analyze molecular kinetics of channels at 9-37°C. Irvine et al developed a Markov model for Na channel using Neuronal Network Model ...

Cardiac sodium channels are integral membrane proteins whose structure is not known at atomic level yet and their molecular kinetics is still being studied through mathematical modeling. This study has focused on adapting an existing model of cardiac Na channel to analyze molecular kinetics of channels at 9-37°C. Irvine et al developed a Markov model for Na channel using Neuronal Network Model ...

The steady-state potassium conductance gK( Xo) of the Rana node of Ranvier is a sigmoid function of membrane potential which ranges from 0 to perhaps 0.15 ,umho (Dodge, 1963). This voltage-dependent increase in potassium conductance could be achieved by various physical mechanisms, but two limiting cases may conveniently be distinguished: On the one hand, each individual channel might have only...

secondary flow investigation could be regarded as an important issue in open channel flow, in spite of its lower quantity compared to the base flow in the water course. it should be given special consideration because of the influence on some hydraulic factors in open channel, specifically in compound channels. in compound channels' due to the difference in the flow velocity of the main ch...

Human HeLa cells transfected with mouse Cx45 and rat RIN cells transfected with chicken Cx45 were used to study the electrical and permeability properties of Cx45 gap junction hemichannels. With no extracellular Ca(2+), whole-cell recording revealed currents arising from hemichannels in both transfected cell lines. Multichannel currents showed a time-dependent activation or deactivation sensiti...

Introduction Numerous studies have demonstrated the presence of potassium selective channels in membranes internal organelles. These channels are essential to a large variety of cellular processes including intracellular 2+ a signaling, protein recycling, charge neutralization and cell protection. In contrast to the sarcoplasmic reticulum + here potassium channels have been clearly ...