The hemispheric, bi-layered optic cup forms from an oval optic vesicle during early vertebrate eye development through major morphological transformations. The overall basal surface, facing the developing lens, is increasing, while, at the same time, the space basally occupied by individual cells is decreasing. This cannot be explained by the classical view of eye development. Using zebrafish (...

The cell coats of the presumptive lens cells and the extracellular interface between the lens rudiment and optic vesicle were investigated in the chicken embryo throughout the period during which lens induction is presumed to take place. Histochemical methods showed that the cell coats contained both glycoproteins and glycosaminoglycans. Autoradiography after [3H]glucosamine injection indicated...

purpose: to compare the results of implantation of intraocular lens (iol) haptics in ciliary sulcus versus optic capture through the posterior capsulorrhexis following iol implantation in capsular bag in pediatric cataract surgery. methods: eighteen eyes of nine children with bilateral congenital or developmental cataract were included in this contralateral prospective randomized study. all cas...

A 42-year-old woman was admitted to our clinic with a complaint of glare in both eyes. Biomicroscopic examination of both the eyes revealed iris and lens colobomas in the inferior quadrant. Fundus examination of the right eye revealed an oval and gray inferotemporal optic pit and two choroid colobomas in the inferior quadrant. In the left eye, two choroid colobomas were detected that were infer...

extended period, whereas the peripheral optic may be protected by the iris. In the present case, the lesions characteristic of snowflake degeneration were restricted to the central 2 mm of the lens optic in the dry state. This is the smallest area we have ever observed and may be related to the fact that the patient’s pupils were relatively constricted as noted on the examination before and aft...

Ultrasonography is the only practical method for obtaining images of the posterior segment of the eye when the light-conducting media are opaque. In this study, 182 dogs with ocular abnormalities presented to the Department of Veterinary Surgery and Radiology from December 2008-August 2010 were included. All the animals were subjected to detailed ophthalmic examination and B-scan ultrasonograph...

In mature mammals, retinal ganglion cells (RGCs) are unable to regenerate their axons after optic nerve injury, and they soon undergo apoptotic cell death. However, a small puncture wound to the lens enhances RGC survival and enables these cells to regenerate their axons into the normally inhibitory environment of the optic nerve. Even when the optic nerve is intact, lens injury stimulates macr...

Background: Palliative whole brain radiotherapy (WBRT) has been the standard treatment for brain metastases. Ionizing radiation is known to be one of the most potent cataractogenic agents. We aimed to evaluate two different radiotherapy techniques with respect to the doses received by the organs at risk (OAR) in patients with brain metastasis who undergone WBRT. Materials and Methods: Ten conse...

Objective(s) Extracellular matrix (ECM) and basement membrane (BM) play important roles in many developmental processes during development and after birth. Among the components of the BM, collagen fibers specially type IV are the most important parts. The aim of this study was to determine the time when collagen type IV appears in the BM of lens structure during mouse embryonic development. M...

Intact bovine lenses have been studied using the polarized Raman spectroscopic technique. A brief theoretical and experimental review of Raman spectroscopy is presented. From the dependence of the Raman depolarization ratio on the propagation direction of the incident radiation we have determined that the uniaxial qualities of the lens result from microscopic anisotropy and have established the...