Background: Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. Objective: The present study was undertaken to investigate the effect of TNZ on the pharmacokinetics of NFX in healthy volunteers. Methods: This study was conducted as an open-label, randomized, two-way crossover experimental design. After an...

Background: Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. Objective: The present study was undertaken to investigate the effect of TNZ on the pharmacokinetics of NFX in healthy volunteers. Methods: This study was conducted as an open-label, randomized, two-way crossover experimental design. After an...

A number of major studies in the past 4 years have facilitated assessment of drug interactions with the steroids in oral contraceptive (OCs). In 8 women receiving a single dose of Minovlar during rifampicin therapy and another dose 1 month after stopping rifampicin, rifampicin reduced the half-life of norethisterone from 6.2 to 3.2 hours, the half-life of ethinyl estradiol (EE) from 6.5 to 2.9...

reveal leukaemia. Bone pain and arthralgias are common presenting symptoms of childhood [3], often accompanied by fever and raised ESR. Interestingly, children with leukaemia who present with musculoskeletal symptoms often have low peripheral leukocyte numbers and few, if any, peripheral blasts [7, 8]. In conclusion, periodic fever accompanied by skeletal pain or profound anaemia should alert t...

conclusions we conclude that oral cancer is etiologically related to the interaction between smoking and drinking. results the smoking as well as alcohol drinking rates in the subjects of the case group were significantly higher than the controls. of smoking types, bidi (a hand rolled cigarette) (or = 4.1, 95% ci = 2.4-6.9), and among alcohol types, hard liquor (or = 2.6, 95% ci = 1. 4-6.4), cou...

Background and objectives: Hypericum perforatum L., commonly known as St. John’s wort (SJW) from the family Hypericaceae is a famous medicinal plant used to treat mild to moderate depression; so, it might affect the pharmacokinetics of numerous drugs. Due to widespread herb-drug interactions of SJW, this study was designed to review the clinical evidences regarding the...

This report is based on an action research multiple baseline design study across five different qualitative aspects of spoken interaction used to evaluate the effectiveness of a flashcard system to improve oral performance in the ESL classroom. The participants were ten children attending third grade in a public school in Bogotá, and who were assessed as having low oral performance in spoken En...

the effect of daily oral administration of ephedrine (0, 1, 2, 4 or 8 mg kg-1 w0.75) on carcasscharacteristics of forty-four 2 yr old crossbred (mehraban x ghezel) fat-tailed ewes was studied. theewes were fed a fattening ration, and received ephedrine by using a drenching gun for either 50 or 70days. there was a significant interaction (p

Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...