oral mucosa can be affected in many systemic diseases such as chronic renal failure (crf). many metabolic and hematologic disorders develop in patients with crf which can also affect oral cavity. oral mucosa, teeth, salivary glands and jaw bones are affected. although hemodialysis can improve many of systemic features but the best treatment is renal transplantation. in addition to previous feat...

I m A a l a e d a i c owadays, patients with AIDS can live a life with considerble quality in relation to oral health, being healthy enough o tolerate most surgical and dental procedures. Furtherore, several studies have shown that patients with HIV isease are not more susceptible to complications, regardess of CD4-cell counts. There are no oral lesions that are specific to HIV patients. ll les...

Genodermatoses consign to an inherited skin disorder associated with structure andfunction. Several genodermatoses present with multisystem involvement lead to increased morbidityand mortality. Many of these disorders are rare and also have oral manifestations, called oralgenodermatoses. This article provides a focused review of molecular basis of importantgenodermatoses that affects the oral c...

Acquired Immunodeficiency Syndrome (AIDS) is a complex of symptoms and infections caused by the HIV virus as it impacts the immune system. It is an acquired infection, not hereditary. AIDS since its appearance in 1981 has spread to become a major cause of prema‐ ture death and so far a cure has not yet been found. The diagnosis of HIV/AIDS requires a positive HIV antibody test or evidence of HI...

Osteopetrosis is a hereditary disorder of bone characterized by sclerosis of bone and decreased marrow spaces. Due to depressed marrow function, this disorder can cause anemia, hepatosplenomegaly, recurrent infections and osteomyelitis of jaw. Excessive bone deposition in skull base leads to narrowing of foramina and cranial nerve compression. Bone marrow transplantation is the only curative tr...

D iabetes is a clinically and genetically heterogeneous group of metabolic disorders manifested by abnormally high levels of glucose in the blood. This hyperglyce-mia results from either a deficiency of insulin secretion caused by pancreatic β-cell dysfunction or resistance to the action of insulin in liver and muscles, or both (1). Periodontal disease is one of the most common chronic inflam-m...

The past decade has shown a significant rise in the prevalence of infective syphilis in the developed world, and striking increases in its frequency have occurred in Eastern Europe, particularly the UK, and in the US. Although oral manifestations of syphilis are most likely to be observed during secondary disease, all stages of the disease can give rise to oral lesions. Significant oral lesions...

J Dent Health Oral Disord Ther 2017, 7(4): 00247 cognitive changes, urogenital infections, skin changes and vaginal dryness. The fact that periodontal tissues are significantly influenced by sex steroid hormones relies on the increased incidence and severity of periodontal diseases during periods of hormone fluctuations, retention and metabolic conversion of sex steroid hormones and the presenc...

Primary hyperoxaluria is a rare, inherited autosomal recessive disease caused by defects in the metabolism of glyoxylate. Oral manifestations of hyperoxaluria are rare. However, bone and tooth resorption may be the result of chronic inflammation and the presence of osteoclastic cells surrounding the oxalate crystal deposit. A deposit of calcium oxalate in the periodontium was identified in a pa...