patients and methods sixty children aged between 2 and 12 years, and scheduled for on-pump surgery due to a congenital heart disease were randomly assigned into two groups. oral midazolam (0.5 mg/kg up to 15 mg per patient) and dexmedetomidine (2 µg/kg) were administered 45 minutes pre-anesthesia. children’s anxiety, mask acceptance behavior, hemodynamic measures, and cardiopulmonary outcomes w...

BACKGROUND This study aimed to compare sedative and analgesic effects of oral Midazolam and Ketamine on Bone Marrow aspiration (BMA) and Lumbar Puncture (LP). MATERIAL AND METHODS This study was a randomized clinical trial and was performed in Amirkola Hospital in north of Iran, Babol during 2011 and 2012 .The study population consisted of 40 patients who underwent the first time of diagnosti...

BACKGROUND Relieving preoperative anxiety is an important concern for the pediatric anesthesiologist. Midazolam has become the most frequently used premedication in children. However, new drugs such as the α(2) -agonists have emerged as alternatives for premedication in pediatric anesthesia. METHODS One hundred and twenty children scheduled for adenotonsillectomy were enrolled in this prospec...

Background Premedication with orally administered benzodiazepines is effective in reducing anxiety and discomfort related to endoscopic procedures. We evaluated the efficacy and safety of oral midazolam in comparison to sublingual alprazolam as premedication for esophagogastroduodenoscopy (EGD). Materials and Methods Adult candidates for diagnostic EGD received either oral midazolam (7.5 mg i...

Background In the pediatric emergency department, patients are commonly treated with a single dose of oral midazolam for minor procedures. We sought to evaluate the effect of this treatment on procedure completion rates. Methods We conducted a single-center retrospective cohort study of all patients who were treated with pre-procedure oral midazolam between January 2011 and June 2016. The pri...

BACKGROUND To compare oral midazolam (0.5 mg/kg) versus oral clonidine (4 μg/kg) as a premedication in pediatric patients aged between 2-12 years with regard to sedation and anxiolysis. METHODS Sixty pediatric patients belonging to the American Society of Anesthesiologists class I and II between the age group of 2-12 years scheduled for elective surgery were randomly allocated to receive eith...

We conducted this single blind randomized clinical trial to compare the efficacy and safety of oral chloral hydrate and intranasal midazolam for induction of sedation for computerized tomography scan of brain in children. Participants aged 1-10 years (n=60) were randomized to receive 100 mg/kg chloral hydrate orally with intra nasal normal saline OR intranasal midazolam 0.2 mg/kg with oral norm...

Objectives: The objectives of this study are to evaluate the efficacy midazolam as a means conscious sedation in pediatric odontology through three routes administration: oral, rectal and nasal administration, compare these different assess general safety Midazolam. Materials Methods: Thirty healthy non-cooperating (ASAI) patients (levels 1 2 on FRANKL scale), aged 5 years requiring minimum den...

OBJECTIVE The purpose of this study was to evaluate the efficacy of injection midazolam administered by oral route mixed in paracetamol syrup as a premedication in children undergoing surgery. METHODS 60 children undergoing elective hernia repair under general anaesthesia were randomized into two groups: the study group (group A) was given oral midazolam 0.5 mg/kg (mixed in paracetamol syrup)...

BACKGROUND Midazolam is a water soluble benzodiazepine which is frequently administered by intravenous and oral routes in our institution. Its nasal spray has become recently available. OBJECTIVES To compare the efficacy of midazolam administered orally and by intranasal spray, with the specific objective of assessing their efficacy in terms of acceptability to the patients, whether they achi...