The development of organelle-specific fluorescent probes has been impeded by the absence a comprehensive understanding relationship between physicochemical properties and their selectivity towards specific organelles. Although few machine learning models have suggested several parameters that control target organelle attempted to predict organelles, they challenged low accuracy limited range ap...

One of the near-to-invariant hallmarks of early apoptosis (programmed cell death) is mitochondrial membrane permeabilization (MMP). It appears that mitochondria fulfill a dual role during the apoptotic process. On the one hand, they integrate multiple different pro-apoptotic signal transducing cascades into a common pathway initiated by MMP. On the other hand, they coordinate the catabolic reac...