The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities. Expansion and refinement in the field of asymmetric organocatalysis have made possible the development of straightforward strategies that addres...

The chemical upcycling of poly(bisphenol A carbonate) was carried out through organocatalysis using α-hydroxyketones as nucleophiles, leading to valuable vinylene carbonates.

Abstract The 2021 Nobel Prize in Chemistry was awarded jointly to Benjamin List and David MacMillan “for the development of asymmetric organocatalysis.” This choice remarkable for a number reasons. It singled out very “chemical” discovery, whereas recent years, chemistry prizes often went discoveries biochemistry, it two relatively young men. concept organocatalysis has been around since late 1...

SOMO catalysis has lately obtained large interest as a new and powerful version of enantioselective organocatalysis which includes radical steps initiated by a one-electron oxidation. The intermediate enamine radical cation has been postulated, but has not been observed directly so far. This communication now reports the direct detection of this key intermediate.

The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric a-allylation of carbonyl compounds, a-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-func...

A one-pot, multistep reaction cascade to cyclopentenes from alpha,beta-unsaturated ketones and propargylated carbon acids through a combination of organocatalysis and transition metal ion catalysis is reported; the reaction cascade is simple to perform, occurs under mild conditions and is broad in scope.

Organocatalysis has been a breakthrough in chemical transformations becoming viable the conversion of challenging reactions through sustainable use small organic molecules as catalysts [...]