Copper-catalyzed enantioselective borylative cyclization with various electrophiles via difunctionalization of unsaturated hydrocarbons is a powerful tool for the generation interesting boron-containing carbocycles and heterocycles processes involving chiral organocopper intermediate. Alkenes, allenes, alkynes are versatile easily accessible substrates that can be subjected to wide range reacti...

A copper complex has proven to be a potent catalyst for forming a C-B bond via diborylation of arynes and alkynes, affording vic-diborylarenes and vic-diborylalkenes with high efficiency. A boryl-substituted organocopper species, which is intermediately generated in the diborylation, has been found to be captured by a tin or a carbon electrophile, leading to three-component borylstannylation or...

The reaction mechanism of the Cu+-catalyzed introduction two all-carbon-substituted stereocenters in an ynamide system using a Grignard reagent, zinc carbenoid, and aldehyde, was investigated density-functional theory. In contrast to formation organocopper(I) compound subsequent carbocupration reaction, previously postulated as initial step, proved instead proceed through complexation substrate...