Non-syndromic cleft lip/palate (NSCL/P) is a complex, frequent congenital malformation, determined by the interplay between genetic and environmental factors during embryonic development. Previous findings have appointed an aetiological overlap between NSCL/P and cancer, and alterations in similar biological pathways may underpin both conditions. Here, using a combination of transcriptomic prof...

Cleft lip with or without cleft palate (CL/P) is one of the most common birth defects; it is a multifactorial disease affecting > 1/1,000 live births in Europe, and its etiology is largely unknown, although it is very likely genetic and environmental factors contribute to this malformation. Orofacial development is a complex process involving many genes and signaling pathways. Mutations in the ...

background: currently, orofacial sequelae are recognized as very influential on the qualityof- life for a victim of orofacial damage. therefore, correct forensic assessment for indenisation purposes is mandatory. however, orofacial damage is frequently reduced to organic components, which results in a forensic assessment process, which are inadequate. this study aims to improve the orofacial da...

Context: Cleft Lip and Palate (CL/P) is the most common craniofacial malformation in oral cavity, with a prevalence of “1 to 2in 1,000 live births worldwide. Parents CL/P children are more prone experience emotional disorders, especially depression, have higher child-related stress than parents normal children. Due effect mental status on children, assessment psychological aspects this problem ...

Purpose: Orofacial function is the result of complex activities of the central nervous and neuromuscular systems. Orofacial dysfunction can compromise vital actions, such as breathing, chewing and swallowing, and facial expressions. The aim of this study was to apply the Brazilian version of the Nordic Orofacial Test–Screening (NOT-S), which assesses orofacial dysfunction, to a sample of Brazil...

Background Chronic orofacial pain conditions such as trigeminal neuropathic pain, reflex sympathetic dystrophy of the face, and temporomandibular pain disorders are debilitating pain conditions. They are known to respond poorly to treatment including opioids in human patients. There is a pressing need to better understand the mechanisms of these chronic orofacial pain conditions so that new and...

abstract we had two cases of female complicated anorectal and genital malformations which underwent total mobilization of all structures of perinea to midline. case1: a 6 month old female with skin covered bladder, pubic diastasis, ectopic anus, vagina, and urethra to the right side of median cleft and lipoma on the left side. closure of pubic diastasis with iliac osteotomy and double barrel si...

Orofacial granulomatosis (OFG) is a granulomatous disease of the orofacial region which appears usually as a persistent and/or recurrent labial soft tissue swelling in the orofacial region and is characterized histologically by a granulomatous inflammation. OFG may cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. Thi...

The year 2013-2014 has been designated the Global Year Against Orofacial Pain by the International Association for the Study of Pain. Accordingly, a multidisciplinary Canadian and international group of clinical, research and knowledge-transfer experts attended a workshop in Montreal, Quebec. The workshop had two aims: to identify new pathways for innovative diagnosis and management of chronic ...

Pain in the oral and craniofacial system represents a major medical and social problem. Indeed, a U.S. Surgeon General’s report on orofacial health concludes that, ‘‘. . .oral health means much more than healthy teeth. It means being free of chronic oral-facial pain conditions. . .’’ [172]. Community-based surveys indicate that many subjects commonly report pain in the orofacial region, with es...