Oral squamous cell carcinoma (OSCC) is an aggressive, invasive malignancy of epithelial origin. The progression from premalignant lesions-oral leukoplakia (OLK) and oral lichen planus (OLP)-to OSCC involves complex inflammatory processes that have not been elucidated. We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to...

UNLABELLED Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer that develops from the epithelium of the oral cavity. OSCC is on the rise worldwide, and death rates associated with the disease are particularly high. Despite progress in understanding the mutational and expression landscape associated with OSCC, advances in deciphering these alterations for the development of therape...

In Europe and the US the incidence of oropharyngeal squamous cell carcinoma (OSCC), where tonsillar and tongue base cancer dominate, has increased and we propose this is due to an epidemic of human papillomavirus (HPV) infection. We base our hypothesis on two main findings. Firstly, in the past decade numerous reports have shown the presence of HPV in OSCC, and that HPV-positive OSCC has a sign...

Molecularly targeted drugs are used in the treatment of a variety of malignant tumors, but this approach to developing novel therapies for oral squamous cell carcinoma (OSCC) has lagged behind the progress seen for other cancers. We have attempted to find appropriate molecular targets for OSCC and identified cell division cycle associated 5 (CDCA5) as a cancer-related gene which was overexpress...

Lymph node involvement is the most important predictor of survival rates in patients with oral squamous cell carcinoma (OSCC). A biomarker that can indicate lymph node metastasis would be valuable to classify patients with OSCC for optimal treatment. In this study, we have performed a serum proteomic analysis of OSCC using 2-D gel electrophoresis and liquid chromatography/tandem mass spectromet...

Objective: Cyclin D1 promotes cell cycle progression during G1 phase, a key event in G1-S transition. It is positive regulator of cycle. Overexpression may lead to disturbance normal control and tumor formation. The objective the study was evaluate expression cyclin varying grades oral squamous carcinoma (OSCC). Methods: Nine formalin-fixed paraffin embedded tissues were immunohistochemically a...

Failure or delay in the early diagnosis of oral squamous cell carcinoma (OSCC) is one of the primary causes of high mortality and morbidity in cancer patients (Ferlay et al., 2004). Further insights into the mechanisms leading to malignancy are prerequisite for identifying new biomarkers for OSCC from the serum. The idea of screening and following patients with malignancy by serum analysis is a...

Oral squamous cell carcinoma (OSCC) remains the main cause of cancer mortality, accounts for 90% of oral cancers. Increasing evidence reveals that aberrant expression of microRNA contributes to the development and progression of OSCC, but the roles of microRNA-506 (miR-506) in OSCC remain elusive. Here, we found that the expression of miR-506 was decreased in 21 OSCC tissues and SCC-4 and SCC-9...

Although carcinogenesis of oral squamous cell carcinoma (OSCC) has been studied by many investigators in the past decade, the available evidence about its molecular mechanism is inconclusive. The objective of the present study was to compare expression of Smad4, a signaling molecule of the transforming growth factor beta (TGF-beta) pathway, between OSCC and normal oral mucosa. We assayed expres...

BACKGROUND The development of oral squamous cell carcinoma (OSCC) involves genetic mutations, epigenetic gene expression modification, and other processes. It has been reported that IFI27 is upregulated in OSCC, but its function is unknown. The aim of this study was to investigate the role of IFI27 on OSCC cell proliferation and invasion. METHODS The protein level of IFI27 in OSCC tissues and...