In the modern era of treatment many new approaches have been evolved for more efficient administration of drugs. One of such approach is the administration of drugs at times at which they are most effective and best tolerated. Chronotherapy is the approach where the availability of drug is timed to match rhythms of disease or disorders in order to optimize therapeutic responses and minimize sid...

The pharmacological activity of herbal medicine is an overall action of each component in accordance with their original proportion. An efficient, sustained, and controlled-release drug delivery system of herbal medicine should ensure the synchronized drug release of each active component during the entire release procedure. In this study, silymarin (SM), a poorly soluble herbal medicine, was s...

The main intention of the present work is to design and evaluate a new Elementary Osmotic Pump (EOP) for efficient delivery of Poorly Water-Soluble Drugs (PWSDs). Drug release from the new system called Expandable EOP (EEOP), is through a porous semipermeable membrane in the form of a suspension ready for dissolution and absorption. EEOP tablets were prepared by compressing the mixture of drug ...

www.pharmtech.com new chemical entity often is first formulated as a free-flowing granulation for encapsulation within hard gelatin capsules. During the course of clinical development, the drugcontaining granulation usually is modified for compaction into a tablet product. The tablet product subsequently may be film coated for taste masking, identification, or other purposes. Tablets are the mo...

An osmotic, oral, controlled-release capsule is described. This capsule provides drug delivery at fixed delivery rates (T(80%)=6 or 14h) independent of drug properties (e.g., solubility) or drug loading, thereby allowing rapid development of investigational or commercial drugs, especially for proof-of-concept type clinical studies. The capsule body and cap are prepared with cellulose acetate an...

Terahertz pulsed imaging (TPI) is a recent and nondestructive technique to quantify coating thickness of pharmaceutical tablet film coatings. In this study, TPI is used for the first time to quantify the progress of an active coating process. The dosage form consisted of a push-pull osmotic system comprising a two-layer tablet core with a functional film coating and a laser drilled hole. On top...

Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study...

Bearing in mind the present scenario of the increasing biological tolerance of bacteria against antibiotics, a time controlled two pulse dosage form of amoxicillin was developed. The compression coating inlay tablet approach was used to deliver the drug in two pulses to different parts of the GIT after a well defined lag time between the two releases. This was made possible by formulating a cor...

Preparation and in vitro and in vivo evaluation of vinpocetine (VIN) elementary osmotic pump (EOP) formulations were investigated. A method for the preparation of VIN elementary osmotic pump tablet was obtained by adding organic acid additives to increase VIN solubility. VIN was used as the active pharmaceutical ingredient, lactose and mannitol as osmotic agent. Citric acid was used as increasi...

Aim: The objective of this study was to identify critical formulation parameters affecting the drug release from controlled porosity osmotic tablet of milnacipran hydrochloride employing the concept of design of experiments. Materials and Methods: The optimized amount of ethocel (X1) and mannitol (X2) in core and percentage of sorbitol (X3) in coat were determined employing a three-factor, thre...