OBJECTIVE To study the impact of thyroxine (T4) withdrawal on serum osteoprotegerin concentrations in women, using a healthy euthyroid control group matched for age and postmenopausal status as reference. SUBJECTS AND DESIGN Nineteen women with differentiated thyroid carcinoma were studied the last day on T4 suppressive treatment, 4-7 days after withdrawal and the day before whole body scanni...

We investigated the regulatory roles of miR-141 and RICTOR genes in osteoporosis (OP) explored potential therapeutic value OP by targeting gene. The role as regulators ovariectomized (OVX) rats was determined using RT-qPCR assays models OVX rats. their expression levels related clinical features were further analyzed. functional miR-141/RICTOR pathway plasmids. lowly expressed rats, while gene ...

Cardiovascular disease is increased in HIV-infected patients. Cytokines such as osteoprotegerin are implicated in atherosclerosis. The aim of our study was to evaluate the role of osteoprotegerin in the development and progression of atherosclerosis in HIV infected subjects on suppressive antiretroviral treatment. We enrolled 76 patients; 35 HIV infected men on suppressive Highly Active Antiret...

The present experiments were carried out to test the hypothesis that arterial calcification is linked to bone resorption by determining whether the selective inhibition of bone resorption with osteoprotegerin will inhibit arterial calcification. In the first test, arterial calcification was induced by treating 22-day-old male rats with warfarin, a procedure that inhibits the gamma-carboxylation...

Purpose: To determine the regulation of the expression of osteoprotegerin and receptor activator of nuclear factor-kappa B ligand in human dental follicle cells by colony-stimulating factor-1, parathyroid hormone-related protein and bone morphogenetic protein-2. Materials and Methods: Primary human dental follicle cells were cultured. The fifth passaged human dental follicle cells were separate...

RANKL is a type II membrane protein bearing close homology to TNFSF members TRAIL, FasL, and TNF-a. has been definite for its key characteristic role in bone metabolism the immune system. It an apoptosis regulator gene, binding partner of osteoprotegerin OPG, ligand receptor RANK, it controls cell proliferation by modifying levels. Osteoblasts stromal stem cells activator NFκ-B (RANKL), binds a...

Estrogen stimulates gene expression and protein production of osteoprote-gerin by human osteoblastic cells. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Immunological characterization of circulating osteoprotegerin/osteoclasto-genesis inhibitory factor: increased serum concentrations in postmeno-pausal women with osteoporosis. Osteoprotegerin an...