نتایج جستجو برای: osteosarcoma cells
تعداد نتایج: 1390988 فیلتر نتایج به سال:
PURPOSE Osteosarcoma and Ewing's sarcoma are the most common bone tumors in children and adolescents. Despite intensive chemotherapy, patients with advanced disease have a poor prognosis, illustrating the need for alternative therapies. Sarcoma cells are susceptible to the cytolytic activity of resting natural killer (NK) cells which can be improved by interleukin (IL)-15 stimulation. In this s...
This study describes a case of giant cell osteosarcoma (GCO) localised on the right scapulae in six-year-old neutered male Scottish Fold cat. GCO is rare tumour domestic animals. also known as cell-rich osteosarcoma. Multinucleated cells and osteoid structures are observed GCO. The mass was 4.6 x 4.4 4.3 cm size very firm. Microscopically, fusiform spindle-shaped multinucleated were observed. T...
Abstract Osteosarcoma (OS) is a common type of bone tumor for which there has been limited therapeutic progress over the past three decades. The prevalence transcriptional addiction in cancer cells emphasizes biological significance and clinical relevance super-enhancers. In this study, we found that Max-like protein X (MLX), member Myc-MLX network, driven by Upregulation MLX predicts poor prog...
While treatments for childhood osteosarcoma have improved, the overall survival for this common type of bone cancer has not changed for three decades, and thus, new targets for therapeutic development are needed. To identify tumor-related proteins in osteosarcoma, we used isobaric tags in a relative and absolute quantitation proteomic approach to analyze the differentially expressed proteins be...
Abstract: Aim/Background: Osteosarcoma is one of the prevalent cancers occurring mostly in adolescents and has a high risk malignancy. With complications involved current treatment strategies, alternates including use phytochemicals have gained fame. Cranberries are known for their exceptional health benefits been explored effective activities various cancers. The study aimed at evaluating anti...
PURPOSE Osteosarcoma is the most common primary malignancy of bone. The long-term survival of osteosarcoma patients hinges on our ability to prevent and/or treat recurrent and metastatic lesions. Here, we investigated the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoid receptors as a means of differentiation therapy for human osteosarcoma. EXPERIMENTAL ...
Osteosarcoma is the most commonly diagnosed malignant bone tumor in humans, with a higher incidence children and young people. It highly aggressive has high metastatic potential. Its treatment based on both chemotherapy surgical intervention. However, currently used chemotherapeutic agents, such as doxorubicin, have several adverse effects patient. Therefore, there growing demand for new agents...
The objective of this study was to analyze the effect of the expression of WWOX and p53 on the growth of MG-63 osteosarcoma cells and to explore the correlation between osteosarcoma and the expression of WWOX and p53. WWOX and p53-overexpressing MG-63 osteosarcoma cell lines were established by transfection and named the MW and MP cell lines, respectively. Untransfected MG-63 cells (blank contr...
Conventional therapy of primary bone tumors includes surgical excision with wide resection, which leads to physical and aesthetic defects. For reconstruction of bone and joints, allografts can be supplemented with mesenchymal stem cells (MSCs). Similarly, adipose tissue transfer (ATT) is supplemented with adipose-derived stem cells (ADSCs) to improve the efficient grafting in the correction of ...
As one common malignant bone cancer, osteosarcoma is mainly occurred in young people with increasing incidences. Current treatment of osteosarcoma includes surgery and chemo-/radio-therapy. Due to the unclear pathogenesis mechanism, the overall treatment efficacy is still not satisfactory. As anti-apoptotic molecule Bcl-2 has been suggested to be related with osteosarcoma and is regulated by mi...
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