INTRODUCTION A boy presented with arthrogryposis multiplex congenita (AMC) associated with severe central nervous system dysfunction. The clinical history and the distinctive radiographic/tomographic features were consistent but not completely diagnostic for dysosteosclerosis. CASE PRESENTATION A 5-year-old boy from a consanguineous family in Austria was born with arthrogryposis multiplex con...

Objective: The aim of this study was to update the concepts diagnosis idiopathic osteosclerosis (IO) jaws by digital panoramic radiographs and cone beam tomography describe impact disease on oral general health. Methods: A search main databases dental medical research carried out using terms “osteosclerosis, radiography, computed tomography, jaws”. Articles without language restriction until Se...

Objective: To determine prevalence of Idiopathic osteosclerosis (IO) by radiographic evaluation and to investigate the relationship between finding in relation with age, gender location Indonesia Sub-Population.
 Material Methods: this was a cross-sectional study that panoramic radiograph patients (1030 male 1914 female) whose age range 10-82 years old who visited Department Oral Maxillofa...

The histopathology of bone is described in 60 patients with chronic renal failure due to a variety of renal diseases. Changes of azotaemic renal osteodystrophy included osteitis fibrosa, osteomalacia, and osteosclerosis. Quantitative histology using a point-counting technique revealed a significant increase in total bone, mineralized bone, and osteoid in comparison with a control group of 68 in...

Breast and prostate cancers are specially metastasizing to bone. Metastases from breast cancer usually exhibit a mixed osteolytic/osteosclerotic aspect, with osteolysis predominating. Osteosclerosis is a common finding in prostatic cancer although osteolysis occurs within the sclerotic lesions. B-cell malignancies (lymphoma, myeloma) are also associated with marked osteolysis. Histopathological...

JAK2 inhibition therapy is used to treat patients suffering from myeloproliferative neoplasms (MPN). Conflicting data on this therapy are reported possibly linked to the types of inhibitors or disease type. Therefore, we decided to compare in mice the effect of a JAK2 inhibitor, Fedratinib, in MPN models of increasing severity: polycythemia vera (PV), post-PV myelofibrosis (PPMF) and rapid post...