نتایج جستجو برای: osthol
تعداد نتایج: 109 فیلتر نتایج به سال:
In the search for new environmental friendly antifouling (AF) agents, four coumarins were isolated from the herbal plant Cnidium monnieri, known as osthole (1), imperatorin (2), isopimpinellin (3) and auraptenol (4). Furthermore, five coumarin derivatives, namely 8-epoxypentylcoumarin (5), meranzin hydrate (6), 2'-deoxymetranzin hydrate (7), 8-methylbutenalcoumarin (8), and micromarin-F (9) wer...
A specific, sensitive, and reliable high performance liquid chromatography with fluorescence detection (HPLC-FLD) was first optimized and then used in the simultaneous quantification of bergapten, imperatorin, notopterol, and isoimperatorin in rat plasma using osthole as the internal standard. Liquid-liquid extraction with ethyl acetate was employed in treating the rat plasma samples obtained. ...
Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophysiological experiments. First, osthole clearly remitted the scratching behavior...
A simple and sensitive high-performance liquid chromatographic (HPLC) method is developed for the determination of osthole in rat plasma and applied to a pharmacokinetic study in rats after administration of Fructus Cnidii extract. After addition of fluocinonide as an internal standard, plasma samples are extracted with diethyl ether. HPLC analysis of the extracts is performed on a Hypersil ODS...
Angelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine, is reported to have central nervous system activities. The purpose of this study was to characterize the blood-brain barrier permeability of twelve coumarins from APR including umbelliferone (1), osthol (2), scopoletin (3), peucedanol (4), ulopterol (5), angepubebisin (6), psoralen (7), xanthotoxin (8), bergapten (9)...
Alzheimer disease (AD) is a complex neurodegenerative disease that leads to the decline in the cognition in elderly people (>65 years of age). Deposition of senile plaques (of amyloid β) and neurofibrillary tangles (of hyperphosphorylated tau) are the typical hallmarks of the disease. AD significantly contributes to the worldwide dementia, which is 46.8 million in 2015 and estimated to 131.5 mi...
The grapefruit (Citrus maxima L.) is a plant known by the public as fruit consumed with various properties. This plant's use well known, such antioxidants, enhancing immunity, anti-aging, and antibacterial study aimed to identify analyze chemical compounds contained in C. rind. extract was obtained maceration method using ethanol ethyl acetate solvents. fractionation process carried out Column ...
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