Instrumentation to evaluate the auditory brainstem response to high-frequency (8-14 kHz) tone bursts has been developed in the Auditory Research Laboratory, Portland, Oregon VA Medical Center. This system is intended to monitor the audition of patients receiving ototoxic drugs who are unresponsive to behavioral test procedures. The reliability of responses obtained with the high-frequency tone-...

Teichomycin A2 is a new antibiotic that is similar to vancomycin. Because vancomycin is reported to be ototoxic, teichomycin A2 was tested for ototoxicity. No evidence of ototoxicity was found. Furthermore, ethacrynic acid, a diuretic that augments the ototoxicity of many drugs, did not enhance ototoxicity with teichomycin A2.

UNLABELLED Several ototoxic drugs are harmful to the human being and lead to problems such as tinnitus, many types of hearing loss, and vertigo. Alcohol is among the main agents considered ototoxic. AIM To study the effects of alcoholism in the vestibular-cochlear system. STUDY DESIGN cross-sectional contemporary cohort. MATERIALS AND METHODS The sample comprehended 37 individuals in the ...

Although artemisinin-based combination therapies (ACTs) are widely viewed as safe drugs with a wide therapeutic dose range, concerns about neuroauditory safety of artemisinins arose during their development. A decade ago, reviews of human data suggested a potential neuro-ototoxic effect, but the validity of these findings was questioned. With 5-10 years of programmatic use, emerging artemisinin...

patients and methods in this cross-sectional study, 791 infants were recruited via non-random sampling. demographic and clinical characteristics of the subjects were gathered, and the automated auditory brainstem response (aabr) test was performed upon admission. afterwards, the subjects were followed-up and re-assessed, using the aabr test. for infants with abnormal aabr results, the auditory ...

Aminoglycosides are broad-spectrum antibacterial agents used in the treatment of urinary tract infections, tuberculosis, visceral leishmaniasis, sepsis newborns, as well cystic fibrosis. However, use aminoglycosides is limited due to their ototoxicity — risk developing serious adverse reactions, particular, persistent irreversible hearing loss and vestibular disorders associated with death hair...

UNLABELLED Some pharmaceutical products are capable of damaging the human auditory system. Technological progress has provided numerous resources to monitor hearing but there still is some controversy regarding the selection of the most sensitive and specific tests. OBJECTIVE to analyze audiological procedures used in the auditory monitoring of individuals exposed to ototoxic medication. ME...