PURPOSE Pigment epithelium-derived factor (PEDF) regulates blood-retinal barrier function. As a constituent of aqueous humor, the role of PEDF in conventional outflow function is unknown. The goals of the study were to examine the effects of PEDF on barrier function of cultured Schlemm's canal (SC) endothelia and outflow facility in mouse eyes in situ. METHODS To model the inner wall of SC, t...

OBJECTIVE Previously, we documented association between CSF circulation and transcranial-Doppler derived autoregulation in non-shunted patients suffering from hydrocephalus. In the present study we sought to investigate the relationship between the resistance to CSF outflow and pressure-reactivity both in shunted and non-shunted NPH patients. MATERIAL AND METHODS Sixty-eight patients (47 non-...

OBJECTIVES This study examined: 1) the impact of myectomy on postoperative mitral regurgitation (MR) and 2) the association between the severity of MR and the left ventricular outflow tract (LVOT) gradient. BACKGROUND For patients with hypertrophic obstructive cardiomyopathy (HOCM) and MR, controversy exists as to whether myectomy alone is sufficient in eliminating MR. Furthermore, the relati...

the objective of this study was to test whether the stimuli of osmotic pressure (op), vfa or ph in the omasum would affect the passage of digesta from the rumen and feed intake in sheep. five experements were carried out. different solutions with specific, op, vfa concentration and ph were infused into the omasal body. rumen digesta volumes and outflow rates (liquid and solid) were measured by ...

THIS study deals with the problem of the regulation of the intra-ocular pressure and the influence of pressure on the formation and the resistance to outflow of the aqueous humour. The main experimental approach has been to analyse the relationship between the steady state intra-ocular pressure and varied rates of flow of fluid through the anterior chamber of living and dead eyes. In the experi...

A survey of CO(3–2) emission from optically visible oxygen–rich Mira variable stars within 500 pc of the sun was conducted. A molecular envelope was detected surrounding 36 of the 66 stars examined. Some of these stars have lower outflow velocities than any Miras previously detected in CO. The average terminal velocity of the ejected material was 7.0 km s 1, about half the value found in Miras ...

PURPOSE To evaluate the relationship between intraocular pressure (IOP) and flow through the trabecular meshwork in isolated anterior segments of human eyes. Outflow facility (C) is thought to decrease proportionally with increasing IOP in human eyes in vivo and in vitro. METHODS Twenty-nine eviscerated human anterior segments were perfused with ascending and descending pressure sequences in ...

or Not To Stent? I read with great interest the paper entitled “Reversibility of Venous Sinus Obstruction in Idiopathic Intracranial Hypertension” recently published in the American Journal of Neuroradiology by Rohr et al. This paper presents the case histories of 3 patients with idiopathic intracranial hypertension (IIH) and venous outflow stenoses. The first patient had an initial resolution ...