A substantial loss of embryos occurs between Days 30 and 40 of pregnancy in the pig under crowded intrauterine conditions, but it is not clear whether this loss affects the growth of adjacent conceptuses. Birth intervals are known to increase with decreasing litter size, but the factors responsible are unknown. Two possibilities are that increased birth weight associated with reduced litter siz...

Pregnancy is a hypercoagulable state due to pro-hemostatic changes in the activity of coagulation factors and fibrinolysis progressively increasing pressure on iliac veins from growing uterus. Thus, it not surprising that there an increased risk for thrombotic events especially pelvic veins. With trauma delivery, particularly caesarian section, accentuated early days postpartum. Multiparity see...

BACKGROUND Research supports that in vitro fertilization causes anxiety and that anxiety can continue into the resulting pregnancy. Most women who have IVF will have a less invasive treatment for infertility prior to IVF; however, it is unclear if specific less invasive treatment cycles impact anxiety that is experienced in the pregnancy resulting from IVF. METHODS A prospective study was con...

OBJECTIVE To test whether adjuvant therapy with acetylsalicylic acid (ASA) and prednisolone (ASA+Pred) could improve the outcome of IVF in good-pregnancy prognosis patients. DESIGN Prospective, randomized study. SETTING University hospital. PATIENT(S) Three hundred ninety-five infertile couples undergoing IVF. INTERVENTION(S) Patients were randomized to receive ASA+Pred (n = 97) or noth...

Infertility caused by ovarian or tubal problems can be treated using In Vitro Fertilization and Embryo Transfer (IVF-ET); however, this is not possible for women with uterine loss and malformations that require uterine reconstruction for the treatment of their infertility. In this study, we are the first to report the usefulness of decellularized matrices as a scaffold for uterine reconstructio...

BACKGROUND There is no consensus as to whether uterine fibroids have any adverse effects on the outcomes of assisted reproduction treatment. This prospective study compared implantation/pregnancy rates of women with and without fibroids undergoing IVF-embryo transfer and measured uterine blood flow indices of the fibroid group. METHODS Patients who had fibroids that, during transvaginal scann...

the success of oocyte donation is influenced by multiple factors. we performed a retrospective analysis to evaluate prognostic factors in oocyte donation cycles. the main outcome measurements including recipient age, donor age, estradiol level in midcycle, the day of transfer and number of transferred embryos were not different in pregnant and non pregnant groups. endometrial pattern but not en...

Yi, Fu-Xian, Ronald R. Magness, and Ian M. Bird. Simultaneous imaging of [Ca ]i and intracellular NO production in freshly isolated uterine artery endothelial cells: effects of ovarian cycle and pregnancy. Am J Physiol Regul Integr Comp Physiol 288: R140– R148, 2005. First published August 5, 2004; doi:10.1152/ajpregu. 00302.2004.—Pregnancy and the follicular phase of the ovarian cycle show ele...

An intimate discourse between the blastocyst and uterus is essential for successful implantation. However, the molecular basis of this interaction is not clearly understood. Exploiting genomic Hbegf mutant mice, we show here that maternal deficiency of heparin-binding EGF-like growth factor (HB-EGF) defers on-time implantation, leading to compromised pregnancy outcome. We also demonstrate that ...