The pivotal problem of comorbidity research lies in the psychometric foundation it rests on, that is, latent variable theory, in which a mental disorder is viewed as a latent variable that causes a constellation of symptoms. From this perspective, comorbidity is a (bi)directional relationship between multiple latent variables. We argue that such a latent variable perspective encounters serious ...

OBJECTIVE Recently, changes have been proposed to DSM-IV diagnostic criteria for post-traumatic stress disorder (PTSD) to refine the diagnosis because of concerns about its construct validity. Specifically, Spitzer et al. suggested narrowing the PTSD definition of trauma, specifying a symptom onset time frame after the trauma, and removing symptoms that overlap with other anxiety and mood disor...

Detecting communities plays a vital role in studying group level patterns of a social network and it can be helpful in developing several recommendation systems such as movie recommendation, book recommendation, friend recommendation and so on. Most of the community detection algorithms can detect disjoint communities only, but in the real time scenario, a node can be a member of more than one ...

community detection is a task of fundamental importance in social network analysis. community structures enable us to discover the hidden interactions among the network entities and summarize the network information that can be applied in many applied domains such as bioinformatics, finance, e-commerce and forensic science. there exist a variety of methods for community detection based on diffe...

OBJECTIVE The aim of this study was to investigate the impact of overlapping functional gastrointestinal disorder (FGID) on the quality of life of patients with nonerosive reflux disease (NERD) and erosive esophagitis (EE). MATERIALS AND METHODS Data from patients with NERD and EE were collected between January 2009 and March 2010. These cases were further stratified into the subgroups of ove...

dr.mirsadraei and colleagues performed an interesting study about the lung hrct findings in chemical warfare patients who suffering from long-term pulmonary complications. they found that air trapping and mosaic attenuation were the most common lung hrct findings. also they divided patients in different clinical entities according to the lung hrct findings (bronchiolitis oblitrans, pulmonary fi...

Overlapping genes pose an evolutionary dilemma as one DNA sequence evolves under the selection pressures of multiple proteins. Here, we perform systematic statistical and mutational analyses of the overlapping HIV-1 genes tat and rev and engineer exhaustive libraries of non-overlapped viruses to perform deep mutational scanning of each gene independently. We find a "segregated" organization in ...

BACKGROUND Two overlapping genes lacL and lacM (lacLM) encoding for heterodimeric β-galactosidase from Lactobacillus reuteri were previously cloned and over-expressed in the food-grade host strain Lactobacillus plantarum WCFS1, using the inducible lactobacillal pSIP expression system. In this study, we analyzed different factors that affect the production of recombinant L. reuteri β-galactosida...

The genomes of most virus species have overlapping genes--two or more proteins coded for by the same nucleotide sequence. Several explanations have been proposed for the evolution of this phenomenon, and we test these by comparing the amount of gene overlap in all known virus species. We conclude that gene overlap is unlikely to have evolved as a way of compressing the genome in response to the...