Methamphetamine (MET) is a stimulant and one of the most abused drugs in worldwide. MET could cause several organ toxicity such as cardiotoxicity. Oxidative stress has been proposed as the main mechanism for MET toxicity. Propofol as a sedative-hypnotic agent has antioxidant property. In this study, we used propofol for attenuating of MET-induced cardiotoxicity in rats. The groups (six rats in ...

The energetic and physiological challenges of spawning migrations in semelparous Pacific salmon (Oncorhynchus spp.) have been well characterized. However, the accompanying costs associated with oxidative stress during this nonfeeding migration and the potential connection to senescence have not been explored. Oxidative stress is caused by an imbalance between free radical production and absorpt...

Background: One of the major factors affecting on male infertility is oxidative stress (OS). Two main sources of ROS production are leukocytes and spermatozoa. The ROS such as tertiary-butyl hydroperoxide (TBHP) may damage and fragmentate to sperm DNA, which can lead to complications in the offspring. In this study, we will investigate the effect of od on DNA fragmentation index (DFI) in sperm ...

background: a reactive oxygen and nitrogen intermediate produced during an inflammatory response is the important part of host-defense strategies of organ-isms to kill the parasite. however, it is not well known whether these intermediates cause dna damage and oxidative stress in goats infected with babesia ovis . the pur-pose of this study was to clarify the effects of babesiosis on basal leve...

conclusions in sum, the results indicate that the consumption of vitamin c can decrease the lipid peroxidation and increase the level of tac, and is ineffective on enzyme and non-enzyme antioxidants and muscle damage. objectives the aim of the present research was to study the effect of endurance swimming training with the consumption of a vitamin c supplement on indices of oxidative stress and...

background: cadmium (cd) is a heavy metal which is widely spread in our surroundings and has a very strong ability to accumulate in the body organs such as spleen. in this study we aimed to determine the genotoxicity and cytotoxicity effects on mice spleen  treated with cadmium. methods: thirty male mice were enrolled in this study and kept in standard conditions. mice were randomly divided int...

background: occupational exposure to excessive level of copper results in many adverse health effects. objective: to measure pulmonary function, oxidative stress, and extent of dna damage in workers of a copper processing industry. methods: 30 men working in a copper processing industry and 30 men matched for age and socioeconomic status (comparison group) were included in this study. pulmonary...

background: oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. the administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. the present study aimed to evaluate the radioprotective efficacy o...