The reaction of hydroxyl-amine hydro-chloride with isatin in ethanol, catalysed with HCl and neutralized with Na(2)CO(3), yielded the one-dimensional coordination polymer, catena-poly[[[aqua-sodium]-di-μ-aqua-[aqua-sodium]-bis-(μ-2-oxoindoline-2,3-dione 3-oximato)] tetra-kis-(oxoindoline-2,3-dione 3-oxime)], {[Na(C(8)H(5)N(2)O(2))(H(2)O)(2)]·2C(8)H(6)N(2)O(2)}(n). The Na(I) atom has a six-coord...

The totality of chemical space is so immense that only a small fraction can ever be explored. Computational searching has indicated that bioactivity is associated with a comparatively small number of ring-containing structures. Pyrrole, indole, pyridine, quinoline, quinazoline and related 6-membered ring-containing aza-arenes figure prominently. This review focuses on the search for fast, effic...

Peptide-based complex biomacromolecules are now optimally assembled by sequential ligation of unprotected peptide segments. However, this approach is still limited by the laborious chromatographic purification and handling steps needed for multiple successive chemoselective couplings, which leads to loss of material. An efficient alternative is solid phase chemical ligation (SPCL) initially dev...

CYP83B1 from Arabidopsis thaliana has been identified as the oxime-metabolizing enzyme in the biosynthetic pathway of glucosinolates. Biosynthetically active microsomes isolated from Sinapis alba converted p-hydroxyphenylacetaldoxime and cysteine into S-alkylated p-hydroxyphenylacetothiohydroximate, S-(p-hydroxyphenylacetohydroximoyl)-l-cysteine, the next proposed intermediate in the glucosinol...

Catalytic hydrogenation of nitrocyclohexane could be an alternative source various useful chemicals: cyclohexanone oxime, cyclohexanone, cyclohexanol, cyclohexylamine and dicyclohexylamine.

A set of oxime carbamates having N-alkyl and N,N-dialkyl substituents were prepared via carbonyldiimidazole intermediates. It was shown by EPR spectroscopy that they underwent clean homolysis of their N-O bonds upon UV photolysis. During photolysis of acetophenone O-allylcarbamoyl oxime, the corresponding oxazolidin-2-onylmethyl radical was detected by EPR spectroscopy, providing the first evid...

This review summarizes the new carbon-carbon bond construction methods based on the radical reaction of imine derivatives. The intermolecular carbon radical addition to oxime ethers proceeded smoothly in the presence of BF3.OEt2. A high degree of stereocontrol in the reaction of oxime ethers was achieved to give amino acid derivatives with excellent diastereoselectivities. The radical reaction ...

A novel photoredox-catalyzed C(sp 3 )–C(sp ) cross-coupling between N -arylamines and cycloketone oxime esters under mild conditions has been accomplished.

In this study, a series of coumarin chromophore-based oxime-esters were designed and synthesized as visible light photoinitiators (PIs).