Oxymatrine, a potent monosomic alkaloid extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.). possesses anti-inflammatory activittyes.  This study was designed to investigate the effects of oxymatrine on nuclear factor–kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)-dependent inflammatory responses in lipopolysaccharide (LPS)-activated microglia. In this paper, BV2...

experimental evidence suggested that sodium ferulate (sf) and oxymatrine (omt) combination had synergistic anti-inflammatory and antioxidant effects. we hypothesized that sf and omt combination treatment might have protective effects on paraquat-induced acute lung injury. in our study, the swiss mice were randomly divided into seven groups, including control, paraquat (pq), sf (6.2 mg/kg/day); ...

An investigation was conducted on the adsorption of oxymatrine (OMT) on a spherical cellulose adsorbent embedded with wattle bark tannin. The results showed that the adsorption of the OMT on the adsorbent was solution pH dependent and the adsorption process followed the Freundlich adsorption isotherm. The adsorption kinetics of the OMT on the adsorbent could be well described by the pseudo-seco...

Use of active site-targeting inhibitor is an effective approach leading to pharmacological inventions. Heat shock cognate protein A8 (HSPA8) has been found as a receptor VGF derived bioactive peptide TLQP-21 in SH-SY5Y cells. So, it was much interest carry out this study order observe whether Oxymatrine (OMTR), HSPA8, inhibits the binding surface intact, live The results confirmed, expected, th...

Oxymatrine (OMTR) is widely used for the treatment of chronic hepatitis B (CHB) in China. Several reports revealed that combination of OMTR and lamivudine reduced the incidence of tyrosine- (Y-) methionine- (M-) aspartic acid- (D-) aspartic acid (D) (YMDD) mutations in CHB patients. The aim of this study was to evaluate the clinical value of oxymatrine in preventing lamivudine induced YMDD muta...