purpose: to evaluate the effect of vertical prism induced stress on binocular visual evoked potentials. methods: using checkerboard stimulus patterns in two spatial frequencies (sfs) of 0.48 cpd as a low sf and 2.18 cpd as a moderate sf reversing with temporal frequency of 4 hz, the effect of increasing visual stress using vertical prisms of 0, 1, 2 and 3 prism diopters on binocular visual evok...

AIM To investigate the effect of pseudophakia on visual electrophysiology. METHODS Right eyes of 60 pseudophakic (study group) age- and sex-matched 60 phakic (control group) volunteers were included. Subjects without any ocular and systemic disease, who had visual acuity of more than 9/10 underwent full-field electroretinogram (ERG), pattern electroretinogram (PERG), pattern visual evoked pot...

Purpose: To demonstrate visual evoked potential (VEP) changes in multiple sclerosis (MS) disease Methods: A case series study of VEP changes in forty-nine patients with definite, probable and possible diagnoses of MS referred to electrophysiology ward from January 2002 to December 2005. Pattern VEP was done for those with good visual acuity (VA), and flash VEP was done for those who did not hav...

The aim of this study was to evaluate the possibility of evaluation of optimal hyperopic correction based on visual evoked potential (VEP) examination results in children that do not cooperate. There are relatively few studies that evaluated the correlation between visual acuity and especially in young hyperopes. We examined 80 children (160 eyes) with hyperopia, divided into two groups: childr...

Sixteen normal subjects and three patients with optic neuritis were studied to determine the effect of decreased retinal illumination on simultaneously recorded pattern electroretinograms (PERG) and visual-evoked potentials (VEP). Using neutral-density filters (NDF), it was found that linear modeling is an excellent fit for VEP/PERG amplitudes and latencies as log functions of retinal illuminat...

Endotoxin tolerance (ET) is a state of reduced responsiveness to endotoxin stimulation after a primary bacterial insult. This phenomenon has been described in several pathologies, including sepsis, in which an endotoxin challenge results in reduced cytokine production. In this study, we show that the NFκ L chain enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed and accumulated in a...

BAFF, an activator of the noncanonical NFκB pathway, provides critical survival signals during B cell maturation and contributes to B cell proliferation. We found that the NFκB family member RelB is required ex vivo for B cell maturation, but cRel is required for proliferation. Combined molecular network modeling and experimentation revealed Nfkb2 p100 as a pathway switch; at moderate p100 synt...

TNF and RANKL mediate bone destruction in common bone diseases, including osteoarthritis and RA. They activate NF-kappaB canonical signaling directly in osteoclast precursors (OCPs) to induce osteoclast formation in vitro. However, unlike RANKL, TNF does not activate the alternative NF-kappaB pathway efficiently to process the IkappaB protein NF-kappaB p100 to NF-kappaB p52, nor does it appear ...

The initial timing of face-specific effects in event-related potentials (ERPs) is a point of contention in face-processing research. The occasional reports of a larger P100 to face stimuli compared to other image categories is often attributed to differences in low-level stimulus characteristics. Separating the P100 from the classic N170 effect has not been done except by adjusting stimuli to c...

Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics combined with degron motif searches, we effectively screened for a more complete set of Fbw7 targets. We identify 89 putative Fbw7 substrates, including several disease-associated proteins. The transcription fac...