Murine teratocarcinoma F9 cells, which remain undifferentiated under standard cell culture conditions, can form cellular layers resembling early embryonic tissues upon induction of differentiation by retinoic acid and cyclic AMP. We have employed a combination of Northern and Western blot analyses to elucidate the regulation of expression of the tyrosine kinase substrate annexin II and its cell...

"Nondrug Treatments for Idiopathic Pulmonary Fibrosis: IPF Part 3." American Journal of Respiratory and Critical Care Medicine, 203(4), pp. P10–P11

The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a) and transient receptor potential vanilloid 5/6 (TRPV5/V6), as well as 5-hydroxytryptamine receptor 1B (5-HT1B), a G-protein-coupled receptor. T...

Objective: To investigate antenatal detection the chromosome abnormalities in high risk pregnancies and correlation between karyotype analysis and FISH (Fluorescent In Situ Hybridization). Method: Were analyzed cytogenetic results from a total of 594 cases between 2008-2009. Amniotic fluid karyotyping and FISH have been offered to pregnant women with genetic risk, using the standard method and ...

was not generated in this three-way translocation. Translocation t(8;18;16)(p11;q21;p13), another three-way translocation variant of t(8;16)(p11;p13) found in a 15month-old boy with AML M5b, also has a structure that could not generate CBP-MOZ but MOZ-CBP, while RTPCR was not performed in this case. Moreover, Murati et al. reported a 72-year-old man with AML M5a having a complex t(8;16)(p11;p13...

Synthetic peptides capable of self-assembling into amyloid-like fibrillar structures are emerging as novel building blocks for biomaterials. They also serve as simple model systems to study the aggregation process involved in amyloid diseases. In this paper, we probe the structure and stability of fibrillar assemblies formed by two designed peptides P11-I (CH3-CO-Q2RQ5EQ2-NH2) and P11-II (CH3-C...

Depression is a mood continuum, ranging from normal but temporary "bad days" to a completely disabling clinical condition characterized by overwhelming despair that lasts for weeks or months. A popular theory is that a breakdown in signaling by the brain neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) is critically involved in the symptoms of clinical depression, but the nature of this d...

Is O2 diffusivity within renal capillaries rate limiting for O2 delivery to hypoxic renal tubules? Equations based on diffusion theory and developed here predict that soluble hemoglobin (Hb) increases O2 diffusivity by a factor of 1 + [442 Hb%/(P50 +[Formula: see text])], where P50 is the partial pressure of O2 at which the Hb is half saturated. To examine the effect of P50 and Hb concentration...