Background & Aim: Diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. According to the evidence of anti-diabetic extract of Biarum Bovei (BB), Effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. Expe...

introduction: pain in the achilles tendon during loading is a very common condition. conservative treatments, such as low level laser therapy (lllt) have been reported to give varying results. recently, a new laser treatment technique, high power laser treatment (hplt) (swiss dynalaser®), was introduced in scandinavia, but has not, to our knowledge, been systematically tested before. the object...

Background & Aims: The current study aimed to investigate the role of catastrophizing as mediator variable in the relationship of neuroticism and extraversion with fear of movement and pain intensity in patients with musculoskeletal pain. Methods: This study was conducted on 200 subjects who were selected through purposive sampling from among the clients of Sh...

OBJECTIVES To evaluate the effect of COMT and OPRM1 gene polymorphisms on the preoperative pain sensitivity in tumor patients. METHODS 300 cases of cancer patients undergoing elective surgery were included, and the Val158 Met loci of COMT gene and OPRM1 loci of A118 G gene were genotyped by PCR-RFLP. Pain threshold and pain tolerance threshold were measured using electrical stimulation to inv...

Sex affects sensitivity to pain (1,2). Testosterone decreases threshold to thermal pain in male rat while lack of it after castration elevates the threshold (3). Testosterone was also shown to alter morphine analgesia in thermal pain testing in rats (4). It is conceivable that pain mechanism is sensitized by testosterone in male rats. We now report on the influence of testosterone on pain thres...