We have previously shown that 3 Ca(2+) ions are released cooperatively and 1 independently from the complex between (Ca(2+))4-calmodulin and skeletal muscle myosin light chain kinase or a peptide containing its core calmodulin-binding sequence. We now have found that three Ca(2+)-binding sites also function cooperatively in equilibrium Ca(2+) binding to these complexes. Replacement of sites I a...

We have previously shown that 3 Ca ions are released cooperatively and 1 independently from the complex between (Ca)4-calmodulin and skeletal muscle myosin light chain kinase or a peptide containing its core calmodulin-binding sequence. We now have found that three Ca-binding sites also function cooperatively in equilibrium Ca binding to these complexes. Replacement of sites I and II in calmodu...

In this paper we show that graphs of “neighbourly” cubical complexes – cubical complexes in which every pair of vertices spans a (unique) cube – have good expansion properties, using a technique based on multicommodity flows. By showing that graphs of stable set polytopes are graphs of neighbourly cubical complexes we give a new proof that graphs of stable set polytopes have edge expansion 1.

Analysis of protein-protein interactions (PPI) is an important issue to understand the biological mechanism of a cellular process. Although large volumes of PPI data have been collected, only a few amounts of PPIs have been elucidated at the functional level. It is required to predict functional types of PPIs. A PPI described in existing pathways, as the KEGG pathways, often corresponds to a pa...

aminocarboxylic acids, such as 2-aminobenzoic acid, react easily with [ir(cod)(pme3)3]cl, (cod=1,5-cyclooctadiene), in thf to produce hydridoaminocarboxylato iridium(iii) complexes in high yields. these octahedral complexes are formed via oxidative addition reaction of the o-h bond of the carboxylic group with the central metal. the starting iridium(i) complex losses the cod molecule, the chlor...

This paper proposes a novel four-dimensional approach to the structural study of protein complexes. In the approach, the surface of a protein molecule is to be described using the intersection of a pair of four-dimensional triangular cones (with multiple top vertexes). As a mathematical toy model of protein complexes, we consider complexes of closed trajectories of n-simplices ( 2,3,4, n =  ),...

A recursion due to Kook expresses the Laplacian eigenvalues of a matroid M in terms of the eigenvalues of its deletion M−e and contraction M/e by a fixed element e, and an error term. We show that this error term is given simply by the Laplacian eigenvalues of the pair (M−e, M/e). We further show that by suitably generalizing deletion and contraction to arbitrary simplicial complexes, the Lapla...

Transactivation-response element (TAR) is a stable stem-loop structure of HIV RNA, which plays a crucial role during the life cycle of the virus. The apical loop of TAR acts as a binding site for essential cellular cofactors required for the replication of HIV. High-affinity aptamers directed against the apical loop of TAR have been identified by the SELEX approach. The RNA aptamers with the hi...