Talon cusp is a rare developmental extra cusp-like projection on the cingulum area of affected anterior teeth that may cause various functional and aesthetic problems. The present report describes a case of bilateral palatal talon cusps on permanent maxillary incisors and the treatment procedure to overcome the clinical problems associated with talon cusps.

This study aims to determine the stability of palatal rugae before and after orthodontic treatment. 50 orthodontic cases were selected with pre- and posttreatment casts and 50 casts were randomly selected as variables. Landmarks on the palatal raphe and rugae were marked on the maxillary casts. Points were made on medial and lateral ends of first, second and third rugae. Each cast was photograp...

The most intense endogenous transforming growth factor (TGF)-/?, expression was detected in osteoblasts and fibroblasts in the mid-palatal suture 24 hours after the start of palatal expansion with an immunohistochemical technique. Based on these data, local effects of transforming growth factor-/?, (TGF-/?,) in the expanding mid-palatal suture of the rat were examined. Single doses of human rec...

Objectives Use of a reliable method to determine the degree of skeletal development of the mid-palatal suture is important in the choice of treatment between orthopedic maxillary expansion and surgical expansion in adolescents and young adults. The aim of this study was to review the new methods for evaluation of mid-palatal suture maturation. Methods Electronic search was conducted in PubMed ...

After antigenic stimulation, CD8(+) T cells undergo clonal expansion and differentiation into CTLs that can mount a strong defense against intracellular pathogens and tumors. SWAP-70-like adapter of T cells (SLAT), also known as Def6, is a novel guanine nucleotide exchange factor for the Cdc42 GTPase and plays a role in CD4(+) T cell activation and Th cell differentiation by controlling Ca(2+)/...

The concept of 'field cancerization' describes the clonal expansion of genetically altered, but morphologically normal cells that predisposes a tissue to cancer development. Here, we demonstrate that biased stem cell competition in the mouse small intestine can initiate the expansion of such clones. We quantitatively analyze how the activation of oncogenic K-ras in individual Lgr5(+) stem cells...

A tandem-loop nickel titanium temperature-activated palatal expansion appliance was developed that produces light, continuous pressure on the midpalatal suture and requires little patient cooperation or laboratory work. The purpose of this study was to compare the effectiveness of the nickel titanium palatal expansion appliance with that of a rapid palatal expansion appliance. The study sample ...

Maxillary rapid palatal expansion (RPE) frequently is used to correct skeletal crossbite. A fixed expander with the expansion screw embedded in palatal acrylic (Haas appliance) often is used. Expansion screws come in varying sizes. Situations such as narrow, high vault palate or collapsed posterior segments of a cleft palate may make it impossible to place the desired size expansion screw, nece...

Cancer is the result of sequential genetic changes over time that transform a cell into a malignant and ultimately invasive entity. The insight that cancerous cells arise from a series of mutations in oncogenes and tumor suppressors, commonly known as multistep carcinogenesis, has been conceptually elaborated and proven in the last 20 years. Although knowledge about late steps of cancerogenesis...

Some highlights in the development of our knowledge about carcinogens as etiological agents for cancer are reviewed briefly. Advances during the past 20 years relating to metabolic activation with the genesis of reactive metabolites, molecular targets and their interactions with activated carcinogens, oncogenes as molecular targets and the dependence on cell proliferation, all relating to the i...