Cyclophilins (CyPs), a member of peptidyl-prolyl cis-trans isomerases (PPIases), are ubiquitously distributed in organisms such as bacteria, yeast, plants and animals. CyPs have diverse biological functions, with some exhibiting antifungal and antiviral activities. In this study, Panax ginseng cyclophilin (pgCyP), a novel gene encoding an antifungal protein from Panax ginseng, was cloned, and i...

Panax ginseng is one of the most widely prescribed herbal medicines for the treatment of cancer, diabetes, chronic inflammation, and neurodegenerative and cardiovascular diseases. Since the use of alternative medicines in combination with conventional therapy may increase the risk of unwanted interactions, we investigated the possible genotoxicity of a water-soluble form of the dry root of P. g...

The ontogeny of perennial polycarpic herb Panax ginseng C.A. Mey. (Araliaceae) under plantation conditions was described. Three periods (latent, pregenerative, and generative) and eight age stages have been identified in the ontogeny of cultivated P. ginseng. The generative period of this species is the longest ontogenetic period, which determines the timing of its cultivation in plantations. D...

A rapid quantification of seven ginsenosides in Du Shen Tang decoction, the decoction of the root of Panax ginseng was investigated by rapid resolution liquid chromatography coupled with tandem mass spectrometry (RRLC-MS/MS). All analytes including seven major constituents, namely ginsenoside-Re, Rg1, Rb1, Rc, Rb2, Rd and Rf were analysed simultaneously in short time and provide good linearity ...

Panax ginseng C.A. Meyer (Korean ginseng) is one of the most valuable medicinal plants, recognised for its neuroprotection and other beneficial health effects. It present in a wide range food products, namely plant supplements (PFS) herbal infusions. However, species, having distinct therapeutic effects, are also known as ginseng, pointing out need authenticating such products. The work aims at...

In traditional Chinese medicine, Panax ginseng C.A. Meyer (PG) invigorates “qi” of kidney, spleen and lung, promotes body fluids production, calms the mind to promote intelligence, while P. quinquefolium L. (PQ) supplies “qi”, nourishes “Yin”, clears fire and promotes body fluid production, both are classified as “restoratives”. P. notoginseng (Burk.) F.H. Chen (PN) removes blood stasis, stops ...

Objective: The present study aimed at evaluating the effect of Panax Ginseng on malondialdehyde (MDA) serum levels during eustress on healthy volunteers. Method: In this study, 65 healthy volunteers were recruited from students of a medical school, with the mean age of 22.61±3.63 years. The volunteers were divided into 2 groups: Group A included 35 participants who were treated by Panax Ginseng...

A rise of the polysaccharide associated with serum proteins has been noted in malignancy and in several other conditions (7). Seibert, Pfaff, and Seibert (4) determined the carbohydrate content of normal plasma protein fractions isolated by the low temperature ethanolic procedure of Cohn et al. (1) and foundconsiderablecarbohydrateto be associated with all globulin fractions. It would be of int...

Ginseng occupies a prominent position in the list of best-selling natural products worldwide. Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius) show different properties and medicinal applications in pharmacology, even though the main active constituents of them are both thought to be ginsenosides. Metabolomics is a promising method to profile entire endogenous metabolite...

BACKGROUND The chemical constituents of Panax ginseng are changed by processing methods such as steaming or sun drying. In the present study, the chemical change of Panax ginseng induced by steaming was monitored in situ. METHODS Samples were separated from the same ginseng root by incision during the steaming process, for in situ monitoring. Sampling was sequentially performed in three stage...