OBJECTIVE To determine the spectrum of pancytopenia with its frequency, common clinical presentation and etiology on the basis of bone marrow examination in children from 2 months to 15 years. DESIGN Observational study. PLACE AND DURATION OF STUDY Department of Paediatrics, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, from October 2005 to March 2007. PATIENTS AND ...

Visceral leishmaniasis (VL), also known as kala-azar (black fever in Hindi), is a disease primarily caused by Leishmania donovani. The most important clinical manifestation of visceral fever. Nonspecific laboratory findings include anemia, neutropenia, eosinopenia, and thrombocytopenia. Definitive diagnosis requires the demonstration either parasite smear or tissue culture (usually bone marrow ...

a rare case of splenic harmartoma in a 31 year old female is reported. she was admitted with splenomegaly, fever and chronic history of epistaxis. routine hematological survey revealed pancytopenia and mild hypercellular marrow. abdominal sonography showed a space-occupying lesion in the spleen which was suspected as malignant tumor. splenectomy was performed and histologic findings were diagno...

Pancytopenia is a reduction in all the three cellular elements of blood; exists in adult when the hemoglobin level is less than 10g/dL, total leukocyte count is less than 4x109/L, and platelet count is less than 150x109/L.1 Pancytopenia can be due to decrease in hemopoietic cell production, ineffective haemopoiesis or peripheral destruction of the cells. The haemopoietic cell production can be ...

Whipple's disease is a systemic infectious disease caused by the bacteria Tropheryma whipplei. The most common clinical manifestations of Whipple's disease are weight loss (92%), hypoalbuminemia and steatorrhea (91%, respectively), diarrhea (72%), arthralgia (67%), and abdominal pain (55%). Neurological signs and symptoms from dementia to oculomasticatory myorhythmia or oculofacioskeletal myorh...

Pancytopenia is characterized by a decreased number of at least two blood cell lines. Pancytopeniamay progress acutely, such as with decreased blood cell counts in fulminant sepsis, disseminated intravascular coagulation, or rapid hemolysis. Alternatively, pancytopenia may evolve insidiously over weeks to months. In this review we focus on the latter group of acquired and congenital pancytopeni...