Acetylsalicylic acid and paracetamol are often formulated together in combination with caffeine, an adjuvant, for the relief of pain, fever and inflammations. A new RP-HPLC method with PDA detection has been developed and validated for the simultaneous estimation of acetylsalicylic acid, paracetamol and caffeine in fixed dose combination tablets. A Brownlee analytical column RP-C8 (5 μm, 150 x ...

Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were ra...

Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were ra...

Chlorpheniramine maleate-paracetamol-caffeine tablet formulation is one of the common over-the-counter drugs used for the treatment of cold and cough. A reversed-phase high-performance liquid-chromatography method has been successfully developed for the simultaneous determination of chlorpheniramine maleate, paracetamol and caffeine in a drug formulation. The RP-HPLC method employed a Phenomene...

Persistent organic pollutants such as pharmaceuticals (iohexol and paracetamol) released into the environment is an environmental problem. Thus our objective to propose effective less expensive method for determination of their concentrations in environment. In this work detection quantification were performed using cyclic voltammetry differential pulse (DPV). The anode used a boron-doped diamo...

This paper describes development and validation of a high-performance liquid chromatographic analytical procedure for simultaneously determination of paracetamol and caffeine in a tablet formulation. The separation was achieved on a C18 column at a flow rate of 1.5 ml/min with UV detection at 220 nm. The mobile phase was composed of 1mM phosphate buffer pH 3.0 – acetonitrile (85:15 v/v) contain...

Apoptosis is genetically programmed cell death, an irreversible process of cell senescence with characteristic features (cell shrinkage, chromatin condensation, DNA fragmentation, apoptotic bodies) different from necrosis. Several effective in vitro methods for qualitative and quantitative detection of apoptotic events have been developed. Chromatin degradation, reductions in cell volume and ot...

A new, simple and sensitive adsorptive stripping voltammetric procedure for determination of paracetamol at a lead film glassy carbon electrode modified with Nafion film (Nafion/PbF/GCE) in pharmaceutical formulations was described. Deposition of lead film on a glassy carbon electrode from 0.1 mol L-1 HNO3 at the potential of -1.4 V was performed. The Nafion film coating was carried out by appl...

Paracetamol (acetaminophen) is one of the most commonly used drugs for the treatment of pain and fever in children, both at home and in the clinic, and is now also found in the environment. Paracetamol is known to act on the endocannabinoid system, involved in normal development of the brain. We examined if neonatal paracetamol exposure could affect the development of the brain, manifested as a...

Paracetamol (acetaminophen) is widely used as an over-the-counter analgesic and antipyretic drug. The aim of this study was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β-glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative stress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure o...