The frequently seen side effect of hyperprolactinemia thought to be the 'price' paid for the antipsychotic treatment of schizophrenia. Various reports have linked the use of risperidone, an atypical antipsychotic drug, with the significant rise of prolactin levels. Thus, we set to assess possible difference between prolactin levels among schizophrenia subtypes in 45 male patients treated with s...

Schizophreniais a mental disorder which is characterized by thoughtsor experiences that seem out of touch with reality, disorganized speech or behavior and decreased participation in daily activities. Difficulty concentration memory may also be present. Schizophrenia mainly affects adolescence young adults. Genes play major role schizophrenia. There are five types schizophrenia (paranoid, hebep...

Various studies indicate that we must consider schizophrenia not as a single disease but as several distinct etiological processes that give rise to characteristic symptoms. In the current study, we aimed to examine prolactin serum levels in unmedicated first-episode and recurrent schizophrenic patients. The prolactin levels were compared among the different schizophrenia subtypes, i.e. paranoi...

Trusting people requires evaluating them to assess their trustworthiness. Evaluating a stranger's intentions is likely to be one method of assessing trustworthiness. The present study tested the hypothesis that judgments of trustworthiness are associated with mind reading skills, also called theory of mind (ToM). We tested a group of healthy participants and a group of patients with paranoid sc...

Connectionist-model simulations of competing hypotheses of cognition in schizophrenia were constructed and tested. Emphasis was placed on judgment of affect, a prominent area of disturbance in this disorder with potential implications for social impairment. Participants with paranoid or nonparanoid schizophrenia and control participants provided judgments of affect as expressed in photographic ...

Patients with schizophrenia show impairments of attention and neuropsychological performance, but the extent to which this is attributable to antipsychotic medication remains largely unexplored. We describe here the putative influence of the dose of antipsychotic medication (chlorpromazine equivalents, CPZ), the antipsychotic serum concentration of dopamine (DA) D2-blocking activity and the app...

It has been proposed that an impairment in gaze determination is responsible for the paranoid symptoms reported in schizophrenia. To address this, we examined the gaze discrimination system in schizophrenia. Thirty-two patients suffering from schizophrenia (20 patients with persecutory delusions and 12 patients without such delusions) were compared to 32 control subjects on two specific tasks. ...

Schizophrenia and autism both feature significant impairments in social cognition and social functioning, but the specificity and mechanisms of these deficits remain unknown. Recent research suggests that social cognitive deficits in both disorders may arise from dysfunctions in the neural systems that underlie social cognition. We explored the neural activation of discrete brain regions implic...