Parathyroid carcinoma is a rare malignancy, and only accounts for 0.5-2% of cases of primary hyperparathyroidism. Less than 10% of parathyroid carcinomas are non-functional, and as such, they have been rarely reported in the literature. Importantly, margin status at resection is related to prognosis, and only a handful of case reports of non-functional carcinoma note this important parameter. H...

BACKGROUND Distinction of parathyroid cancer from atypical parathyroid adenoma (APA) at operation is difficult. The aim of this study was to determine whether parathyroid cancer and APA have different operative findings and long-term outcomes. METHODS A retrospective review was undertaken of patients with suspicious or malignant parathyroid tumours treated between 1974 and 2005. Parathyroid c...

There has been recent interest in the association between buUous erythema multiforme (Basler, 1973), bullous pemphigoid (Parsons & Savin, 1968), pemphigus vulgaris (Saikia, 1972) and Senear-Usher syndrome (Saikia & MacConnell, 1972) with various neoplasms. A 46-year-old male patient presented with pemphigus erythematosus which was refractory to various forms of therapy including large doses of ...

Familial multiple endocrine neoplasia type 1 (FMEN1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, pancreatic islets, and anterior pituitary. The gene for this disease maps to chromosome 11q12-11q13, and allelic loss in this region has been shown in both sporadic and FMEN1-related parathyroid tumors. FMEN1-related pancreatic islet tumors, and rarely in spo...

over the past decades, endocrine pathology has emerged as a distinct clinical subspecialty in the field of surgical pathology. Endocrine pathologists play an essential role in the management of patients with endocrine disorders arising from pineal, hypothalamus, pituitary, parathyroid, thyroid, adrenal, paraganglia, pancreas, gastrointestinal tract, lung, thymus, and urogenital system. recent a...

This work was presented in part at the 4th International Congress of Endocrinology, Washington, D. C., 18-24 June 1972. Dr. Palmieri is a Clinical Investigator at the Veterans Administration Hospital, Oklahoma City, Okla., and Dr. Omenn is the recipient of Career Development Award 43122 from the National Institutes of Health. Address reprint requests to Dr. Palmieri, Section of Endocrinology, D...

Multiple different types of anterior mediastinal masses may be encountered on computed tomography (CT) imaging, and many of these lesions are neoplastic in etiology. These include masses arising from the thymus, thyroid and parathyroid glands, as well as lymph nodes, pericardium, and vessels and nerves. Often, the CT attenuation of the mass can be helpful in narrowing down the differential diag...

Spontaneous neoplasms in 930 control Wistar rats from five carcinogenicity bioassays conducted between 1990 and 1995 were reviewed and compared with review findings in studies between 1980 and 1990. Mean survival at 104 weeks was 55% for males and 60% for females, similar to that of the previous review. A total of 1599 neoplasms was diagnosed in 361 (78%) male and 415 (89%) female rats; 1293 (8...

Primary hyperparathyroidism (HPT), most commonly due to parathyroid adenoma, is a disorder characterized by excessive secretion of PTH. So far, abnormalities in two genes, cyclin D1 and MEN1, have been implicated in the development of parathyroid adenomas. Cyclin D1, now an established Oncogene involved in numerous human cancers, was first identified and recognized as an Oncogene in the study o...