Fungal skin infections are the most common disease worldwide. Superficial mycoses caused by Trichophyton rubrum and T.interdigitale one of leading causes for patients to seek dermatological care. Terbinafine (TRB), acting through squalene epoxidase (SQLE) inhibition, is drug choice curing both species. However, TRB-resistant cases increasing. Between 2013 2021, we examined TRB-sensitivity in 54...

Native tissues are characterized by spatially organized three-dimensional (3D) microscaled units which functionally define cells-cells and cells-extracellular matrix interactions. The ability to engineer biomimetic constructs mimicking these 3D microarchitectures is subject to the control over cell distribution and organization. In the present study we introduce a novel protocol to generate 3D ...

Spitzer Space Observatory IRAC and MIPS photometric observations are presented for 20 white dwarfs with Teff . 20, 000 K and metal-contaminated photospheres. A warm circumstellar disk is detected at GD 16 and likely at PG 1457−086, while the remaining targets fail to reveal mid-infrared excess typical of dust disks, including a number of heavily polluted stars. Extending previous studies, over ...

∗ Professor and author of correspondence, Phone: (086) 022-26564242, Fax: (086)022-60204278, Email: [email protected] ABSTRACT The modularity indicates a one-to-one mapping between functional concepts and physical components. It can allow us to generate more product varieties at lower costs. Functional concepts can be described by precise syntactic structures with functional terms. Differen...

The not all equal (NAE) 3-SAT problem is known to be NP-complete even in the absence of negated variables (see [11]), a variant known as positive (or monotone) NAE 3-SAT. In this article, we investigate a related category, dubbed positive NAE LE3SAT (PNAE LE3-SAT), in which each clause has at most three variables, none of which is negated, and an assignment is sought that will satisfy such an e...