Address for correspondence: Michał Sobjanek MD, PhD, Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 1a Kliniczna St, 80-402 Gdansk, Poland, phone: +48 607 039 729, e-mail: [email protected] Received: 8.01.2016, accepted: 20.04.2016. The ethiopathogenesis of psoriasis is complex, multifactorial and still not well understood. Nowadays, the systemic, inflammator...

The liver plays an important role in innate and adaptive immunity and in particular in induction of tolerance. The liver is frequently exposed to pathogens like gutderived food antigens, environmental toxins and bacterial or viral products reaching the liver via the blood flow. It is central for production of acute phase proteins, among others including protease inhibitors, soluble patternrecog...

The innate or natural immune response is the body’s rapid first line of defense for environmental threats (eg, trauma and infection), responding long before an immune defense is mounted.1,2 This response involves a series of reactions that have evolved to limit damage, isolate pathogens (noxious agents), and initiate repair processes. Cells distinguish between pathogen and self by using signals...

Crohn disease pathogenesis is the result of the complex interaction between environmental factors (i.e. micro-flora in the gut), immunologic and genetic predisposition (1, 2). The bacterial pathogenesis hypothesis in Crohn disease is based on experimental data and clinical observation. The first studies in rodent models, such as those in transgenic HLA-B27 rats and many others in mice, demonstr...

Muscular dystrophy encompasses a diverse group of genetically determined muscle disorders. The first clinical description of the disorder is attributed to Giovanni Semmola, who, in 1829, described 2 boys affected by a disorder with prominent muscular hypertrophy.1 Between1850and1868,Aran, Meryon, and Duchenne described a progressive atrophy of voluntarymuscles, ultimately termed pseudohypertrop...

This paper describes the general photographic retrieval and object annotation tasks of the ImageCLEF 2006 evaluation campaign. These tasks provided both the resources and the framework necessary to perform comparative laboratory-style evaluation of visual information systems for image retrieval and automatic image annotation. Both tasks offered something new for 2006 and attracted a large numbe...

T he host antimicrobial defense response is initiated by the innate immune system, the most ancient of the 2 limbs of the immune system. The innate immune system is activated as soon as a pathogen crosses the host external defense barriers, lasts for a few hours, and is aimed at the elimination of the invading microorganism. Detection of microbial pathogens is first carried out by sentinel cell...

This abstract is proposing a challenging problem: to infer a human’s mental state – intent and belief – from an observed RGBD video for human-robot interaction. The task is to integrate symbolic reasoning, a field wellstudied within A.I. domains, with the uncertainty native to computer vision strategies. Traditional A.I. strategies for plan inference typically rely on first-order logic and clos...

A multi purpose sampler (Gerstel MPS), designed for liquid large volume, gaseous and headspace samples was tested for its suitability in the GC-MS analysis of organic volatiles in human urine. Headspace sampling with a volume, temperature and speed controlled gas tight syringe was combined with a temperature controlled cold injection system for cold trapping, enrichment and focussing of analyte...

Design: Sets of differential diagnoses and clinical management plans generated by 71 clinicians for six simulated cases, before and after decision support from a Web-based pediatric differential diagnostic tool (ISABEL), were used. Measurements: A composite quality score was calculated separately for each diagnostic and management plan by considering the appropriateness value of each component ...