Organochlorine compounds, particularly polychlorinated biphenyls (PCBs), alter serum thyroid hormone levels in humans. Hydroxylated organochlorines have relatively high affinities for the serum transport protein transthyretin, but the ability of these compounds to interact with the human thyroid receptor is unknown. Using a baculovirus expression system in insect cells (Sf9 cells), we produced ...

Among the numerous PCB congeners, most of the dioxin-like PCBs (DL-PCBs) need to be characterized by hyphenated techniques. It has been shown in several instances that these congeners are well related to the total PCB content in fish. We examined datasets collected mainly in France, on freshwater and marine fish and sediments. A statistical model linking DL- and indicator PCBs was developed for...

A Monviso clone has been applied to promote PCB degradation in a soil historically contaminated by polychlorinated biphenyls (PCBs) and heavy metals (HMs). The multi-contaminated area is located Southern Italy. PCBs, HMs, the microbial community (abundance, viability, structure) were analysed selected plots of poplar-treated area. At 900 days after poplar planting, chemical analyses showed that...

background: poly chlorinated biphenyls (pcbs) are the groups of organic chemical material and toxic, persistent, bio accumulate and pose a risk of causing adverse effects to human health and the environment. pcb compounds are caused the different health effects in human depending of age, sex, route of entry, intensity and frequency exposure. this study was conducted to determine the effect of m...

background: in this research, the decomposition of aroclor 1254, including 20 kinds of poly chlorinated biphenyls (pcbs), in real waste transformer oil in the presence of peg1000, naoh, zero valent iron and h2o by microwave (mw) irradiation was studied. methods: central composites design (ccd) method was carried out for experimental design. the effects of microwave power levels (200- 1000 w), r...

background: polychlorinated biphenyls (pcbs) are toxic bio-accumulate components and may increase risk of adverse effects on human health and the environment. for different social, technical and economic reasons, significant quantities of pcbs contaminated transformer oil are still in use or storied. the study aimed to determine the effect of hydrogen peroxide and solvent on photolysis of pcbs ...

Hydroxylated PCBs (OH-PCBs) are well-known metabolites of PCBs in organisms, but there has been no direct study of their presence in the abiotic environment. In this study, OH-PCBs were determined in samples of rain, snow, and surface waters from sites in Ontario, Canada. OH-PCBs were quantified by gas chromatography with high-resolution mass spectrometry (GC-HRMS)in order to provide complete c...

Dioxins (PCDD/Fs) and polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants. The contamination of food products with dioxins and PCBs is a well studied issue, because food is generally considered the major source of dioxin intake for humans. In Italy, the Regional Monitoring Plan (part of the national residue monitoring plan) used in the field for 2009 has also included the...

Polychlorinated biphenyls (PCBs) are still the most abundant pollutants in wildlife and humans. Hydroxylated PCB metabolites (OH-PCBs) are known to be formed in humans and wildlife. Studies in animals show that these metabolites cause endocrine-related toxicity. The health effects in humans have not yet been evaluated, especially the effect on the fetus and newborn. The aim of this study is to ...

BACKGROUND Polychlorinated biphenyls (PCBs) are a family of structurally related chlorinated aromatic hydrocarbons. Numerous studies have documented a wide spectrum of biological effects of PCBs on human health, such as immunotoxicity, neurotoxicity, estrogenic or antiestrogenic activity, and carcinogenesis. The role of PCBs as etiologic agents for breast cancer has been intensively explored in...