OBJECTIVES To examine the cost-effectiveness of primary debulking surgery (PDS) when compared to neoadjuvant chemotherapy (NACT) in the management of epithelial ovarian cancer (EOC) using Surveillance, Epidemiology, and End Results data linked to Medicare claims (SEER-Medicare). METHODS Using a Markov model, the cost-effectiveness of PDS was compared to that of NACT. We modeled cost and survi...

BACKGROUND Pericardial decompression syndrome (PDS) is a rare and potentially fatal complication of pericardial drainage, either by needle pericardiocentesis or surgical pericardiostomy. It manifests with paradoxical hemodynamic deterioration and/or pulmonary edema, commonly associated with ventricular dysfunction. We sought to elucidate factors associated with mortality in PDS. METHODS MEDLI...

The development of Product Design Specifications (PDS) is an important part of the product development process. Incompleteness, ambiguity, or inconsistency in the PDS can lead to problems during the design process and may require unnecessary design iterations. This generally results in increased design time and cost. Currently, in many organizations, PDS are written using word processors. Since...

Purpose – The suitability of the project delivery system (PDS) selected for a project greatly influences the efficiency with which the project is executed. It is not an easy task to select an appropriate PDS as a large amount of ambiguous information exists. The aim of this paper is therefore to develop a PDS selection Model to help owner’s decision-making. Design/methodology/approach – Similar...

CONTEXT Although both genetic and environmental factors affect risk of individual personality disorders (PDs), we know little of how they contribute to the pattern of comorbidity between the PDs in the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV). OBJECTIVE To clarify the structure of the genetic and environmental risk factors for the 10 DSM-IV PDs. DESIGN...

BACKGROUND Acute kidney injury (AKI) is a serious complication of systemic inflammatory response syndrome (SIRS), which has a high mortality rate. Previous studies showed that panaxadiol saponin (PDS) and Dexamethasone have similar anti-inflammatory properties and protect cardiopulmonary function in lipopolysaccharide (LPS)-induced septic shock rats. In the present study, we investigated whethe...

Phytoene synthase (Psy) and phytoene desaturase (Pds) are the first dedicated enzymes of the plant carotenoid biosynthesis pathway. We report here the organ-specific and temporal expression of PDS and PSY in tomato plants. Light increases the carotenoid content of seedlings but has little effect on PDS and PSY expression. Expression of both genes is induced in seedlings of the phytoene-accumula...

Photosynthetic organisms synthesize carotenoids for harvesting light energy, photoprotection, and maintaining the structure and function of photosynthetic membranes. A light-sensitive, phytoene-accumulating mutant, pds1-1, was isolated in Chlamydomonas reinhardtii and found to be genetically linked to the phytoene desaturase (PDS) gene. PDS catalyzes the second step in carotenoid biosynthesis--...

The paper presents a new proof-number (PN) search algorithm, called PDS-PN. It is a two-level search (like PN), which performs at the first level a depth-first Proof-number and Disproof-number Search (PDS), and at the second level a bestfirst PN search. Hence, PDS-PN selectively exploits the power of both PN and PDS. Experiments in the domain of Lines of Action are performed. They show that wit...

BACKGROUND Until now, almost nothing is known about the tumorigenesis of atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Our hypothesis is that AFX is the non-infiltrating precursor lesion of PDS. MATERIALS AND METHODS We performed the world-wide most comprehensive immunohistochemical and mutational analysis in well-defined AFX (n=5) and PDS (n=5). RESULTS In NGS-based mu...