نتایج جستجو برای: pediatric aml and prognosis
تعداد نتایج: 16873517 فیلتر نتایج به سال:
Over the past years, outcomes of patients with acute myeloid leukemia (AML) have significantly improved due to use intensive chemotherapy, more effective supportive therapy, and availability allogeneic hematopoietic stem cell transplantation. This article presents children AML treated in accordance AML-MM-2006 protocol. Our study was approved by Independent Ethics Committee Dmitry Rogachev Nati...
results there were no significant differences between the 4 groups in white blood cell count, hemoglobin, hematocrit, and esr at baseline (p > 0.05). the number of platelet units was remarkably higher, but the number of mpv and hco3 was considerably lower in patients with loss/ failure criteria. conclusions mpv is higher in the case of platelets destruction, and this is commonly observed in inf...
BACKGROUND Controversial data on the expression pattern of microRNA-370 (miR-370) in acute myeloid leukemia (AML) were previously reported. OBJECTIVE To clarify the expression pattern of miR-370 and its clinical implications in pediatric AML patients. METHODS Real-time quantitative PCR was performed to detect the expression of miR-370 in both bone marrow mononuclear cells and sera obtained ...
Despite major improvements in outcome over the past decades, acute myeloid leukemia (AML) remains a life-threatening malignancy in children, with current survival rates of ∼70%. State-of-the-art recommendations in adult AML have recently been published in this journal by Döhner et al. The primary goal of an international expert panel of the International BFM Study Group AML Committee was to set...
objective: signaling pathways such as extracellular regulated kinase/mitogen activated protein kinase (erk/mapk) have increased activity in leukemia. ribosomal 6 kinase (rsk4) is a factor downstream of the mapk/erk pathway and an important tumor suppressor which inhibits erk trafficking. decrease in rsk4 expression has been reported in some malignancies, which leads to an increase in growth and...
CD56 was firstly described as a marker of natural killer cells and has been found expressed in several neoplasms including acute myeloid leukemias (AML), the presence of CD56 antigen on blast cells may influence complete remission and survival. CD19 is a B-lymphocyte marker, whose expression is associated with pediatric AML-M2 and the t(8;21) translocation. The biological and clinical significa...
Evaluation of ATG7 and LC3 Autophagy Genes Expression in Newly Diagnosed AML patients Background and aim: Autophagy, known as cell death type II, is a housekeeping pathway that currently has been worked on in matters of tumorigenesis and leukemogenesis. Therefore, in this study expression levels of ATG7 and LC3 as two key genes are targeted in AML patients. Material and method: This...
Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are characteristic of AML. Zinc finger protein 382 (ZNF382) has been suggested to be a tumor suppressor gene possibly regulated by promoter hypermethylation in various types of human cancer. However, ZNF382 expression and methylation status in pediatric AML is unknown. In the p...
The ecotropic viral integration site-1 gene (EVI1) encodes a zinc finger protein that functions as a transcriptional regulator of hematopoietic stem cell self-renewal and long-term multilineage repopulating activity. The mixed lineage leukemia gene (MLL) rearrangements [i.e. t(11q23)] occur at high frequency in pediatric acute myeloid leukemia (AML) patients with EVI1 overexpression, and EVI1 i...
patients with acute myeloblastic leukemia (aml) with monosomy 7 are a group of patients with refractory aml who have a very poor prognosis. therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (valporic acid, atra) are being investigated as potential treatments for the population of refractory cases of aml. herein, we repo...
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