Germ cell tumors (GCTs) are a heterogeneous group of neoplasms that arise from the primordial germ cells human embryo, which normally destined to produce reproductive sperm, or ova. GCTs can be present in both gonadal and extragonadal GCT sites. Pediatric relatively rare with an incidence 2%-3%. Primary mediastinal very anterior mediastinum. In this report, we case 16-year-old boy primary semin...

One hundred and thirty-seven germ cell tumours occurring in 134 children included in the Manchester University Children's Tumour Registry over a 25-year period have been studied. The incidence and sites of these tumours as seen in a comprehensive population-based registry are presented and the relation between the primary site and histological type is assessed. There were 48 deaths in this seri...

Sclerosing stromal tumor of the ovary is a rare, benign ovarian tumor, seen primarily in young women. We report a 3-year-old girl who presented with a palpable lower abdominal mass. Computed Tomography (CT) study revealed a huge pelvic mass with an enhancement pattern typical of ovarian sclerosing stromal tumor. The diagnosis was confirmed by pathology examination of the surgically resected tum...

1. Abramson, L., S. Pillai, R.Acton et al Successful orthotopic liver transplantation for treatment of a hepatic yolk sac tumor , Journal of Pediatric Surgery, 40, Issue 7 (July 2005), pp 1185-1187–288. 2. Albright, JT. AK. Topham, JS. Reilly, Pediatric Head and Neck Malignancies Arch Otolaryngol Head Neck Surg. 128; 2002:655-659. 3. Filho, B, C Araujo. McHugh, J., B. Carrau, Ricardo L. Kassam,...

Programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD-L1 expression and tumor-infiltrating CD8(+) T cells in formalin-fixed, paraffin-embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germin...

Neoplasms from germ cell origin are a heterogeneous group of tumors rarely seen in the pediatric population, teratoma is the most frequent among them. They can occur in either gonadal or extragonadal locations. Extragonadal teratoma arising from abdominal viscera is very unusual. There are less than a hundred reported cases of gastric teratoma in the worldwide literature. Since the occurrence o...