Background: Previous studies have pointed to the major role of viruses in pathogenesis cancers, especially lymphoproliferative cancers. Objectives: The current study investigated relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome. Methods: From January 2011 December 2012, we entered every new case acute lymphoblastic leukemia, non-Hodg...

Abstract Background Acquired tracheoesophageal fistula (TEF) is a rare presentation in pediatric lymphoma patients. Most heal spontaneously following chemotherapy/radiotherapy without requiring surgery. Case A 10-year-old child presented with persistent after completion of chemotherapy for Hodgkin’s lymphoma. The mid-tracheal location the had significant implications terms airway management. Se...

Hodgkin lymphoma (HL) is one of the most curable pediatric and adult cancers, with long-term survival rates now exceeding 90% after treatment with chemotherapy alone or combined with radiotherapy (RT). Of note, global collaboration in clinical trials within cooperative pediatric HL study groups has resulted in continued progress; however, survivors of pediatric HL are at high risk of potentiall...

moderate nuclear sclerotic cataract in the right eye, and a well-centered posterior chamber intraocular lens in the left eye. No hypopyon was noted. There was a moderate vitreous haze in both eyes with a small area of retinitis along the superior temporal arcade of the left eye. Otherwise, the optic nerve, macula, and periphery were grossly normal in each eye. Given the clinical setting, a diag...

We investigated the prognostic value of interim F-FDG PET/CT (PET-2) in pediatric Hodgkin lymphoma (pHL), evaluating both visual and semiquantitative analysis.Thirty pHL patients (age ≤16) underwent serial F-FDG PET/CT: at baseline (PET-0), after 2 cycles of chemotherapy (PET-2) and at the end of first-line chemotherapy (PET-T). PET response assessment was carried out visually according to the ...

Although previously characterized as a subtype of diffuse large B-cell lymphoma, primary mediastinal lymphoma (PMBCL) is now recognized distinct NHL with unique clinical and biologic features, many which overlap classic Hodgkin lymphoma. PMBCL has peak incidence in the adolescent young adult (AYA) population and, unlike other subtypes NHL, higher among females. Recent studies into molecular bio...

Anaplastic large cell lymphoma (ALCL) is the second most common type of peripheral T and an aggressive mature lymphoma. About 50 to 70% systemic ALCLs are anaplastic kinase positive (ALK +), proportion even higher in pediatric population. The 5-year survival after chemotherapy around 70 80%. But there a subgroup ALK+ ALCL patients who refractory chemotherapy. Brentuximab vedotin approved agent ...

b-cell lymphoblastic lymphoma (b-lbl) is an uncommon subtype of pediatric non-hodgkin lymphoma (nhl) which rarely involves the skin primarily. the positron emission tomography with 2-deoxy-2-[fluorine- 18] fluoro-d: -glucose integrated with computed tomography (18f-fdg pet/ct) scan findings of a 8-year-old boy with cutaneous b-lbl were presented. pet/ct scan demonstrated mild fdg uptake in the ...