Introduction: Nephrotic syndrome (NS) is a common chronic kidney disease in childhood and it mostly idiopathic.  Aim of the Study: To determine if uVDBP measurements can be used as non-invasive prognostic biomarker cases idiopathic NS its relation to Ca/P metabolism.   Methods: This prospective study was carried out on children who were newly diagnosed with nephrotic presented pediatric nephrol...

background: nephrotic syndrome and type 1 diabetes mellitus are two common chronic conditions in children. co-existence of these conditions is an extremely rare finding. case presentation: this report presents a 6-year-old boy who was diagnosed with nephrotic syndrome five years ago and type 1 diabetes mellitus in infancy. renal biopsy showed membranous glomerulonephritis, which is a rare histo...

background and objective: to assess the effectiveness and safety of oral amiloride for the treatment of edema in pediatric patients with idiopathic nephrotic syndrome. methods: a randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. the mean age was 4.3±0.7 years old. after a 2 week washout of diuretic therapy, nephrotic children with edema were randomized into two groups...

OBJECTIVES To evaluate the adaptive competences and behavioral problems in children with nephrotic syndrome, and whether their mothers also showed features of psychosocial stress. DESIGN Prospective case-control study. SETTING Pediatric Out-Patient Department. SUBJECTS Seventy consecutive patients of nephrotic syndrome, between the ages of 4 to 14 years, and their mothers constituted case...

The primary goal of our study was to compare the clinical outcomes between IgM positive and IgM negative nephrotic syndrome patients therefore our study model was set to identify and include all pediatric patients with kidney biopsies performed during the 2000-2015 year period. To achieve this, we accessed the National Center of Pathology database identifying all pediatric patients who had kidn...

In nephrotic syndrome, aberrant glomerular filtration of plasminogen and conversion to active plasmin in preurine are thought to activate proteolytically epithelial sodium channel (ENaC) and contribute to sodium retention and edema. The ENaC blocker amiloride is an off-target inhibitor of urokinase-type plasminogen activator (uPA) in vitro. It was hypothesized that uPA is abnormally filtered to...