Background To enhance ocular bioavailability, the traditional strategies have focused on prolonging precorneal retention and improving corneal permeability by nano-carriers with positive charge, thiolated polymer, absorption enhancer and so on. Glycylsarcosine (GS) as an active target ligand of the peptide tranpsporter-1 (PepT-1), could specific interact with the PepT-1 on the cornea and guide ...

Positron emission particle tracking (PEPT) has offered important insights into the internal dynamics of multiphase flows. High precision and frequency measurements location tracer are required to resolve individual eddies at millimetre scale or smaller. To explore potential PEPT perform these measurements, a model was developed Siemens ECAT “EXACT3D” HR++ positron tomography (PET) scanner Cape ...

Coffee roasting is a heat treatment process that transforms green coffee into product can subsequently be ground and brewed. Understanding critical in developing new downstream processes formulations, as well optimising existing ones. Positron Emission Particle Tracking (PEPT) allows tracking of particles equipment has been used here to characterise particle dynamics beans within spouted bed ro...

1 Speziale MV, Mannino FL, Hastings RH, et al. Parathyroid hormone-related protein in tracheal aspirates of newborn infants. Pediatr Res 1998; 43:660–665 2 Hastings RH, Auger WR, Kerr KM, et al. Parathyroid hormone-related protein and lung injury after pulmonary thromboendarterectomy. Regul Pept 2001; 102:1–7 3 Stern JB, Bernard O, Paugam C, et al. Parathyroid hormonerelated protein in epitheli...

Citation for the published paper: Ahrén, Bo and Winzell, Maria Sorhede and Wierup, Nils and Sundler, Frank and Burkey, Bryan and Hughes, Thomas E. "DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide" Regul Pept, 2...

Machine learning (ML) is used to build a new computationally efficient data-driven dynamical model for single-phase and complex multicomponent particle–liquid turbulent flows in stirred vessel. By feeding short-term trajectories of flow phases or components acquired experimentally given condition via positron emission particle tracking (PEPT) technique, the ML learns primary dynamics from input...

We develop a new algorithm for the tracking of radioactive particles using Positron Emission Particle Tracking (PEPT). The relies on maximization likelihood simple Gaussian mixture model lines response associated with positron annihilation. includes component that accounts spurious caused by scattering and random coincidence, it treats relative activity as well their positions parameters to be ...

Impellers play a key role in flotation cells, as the turbulence generated through agitation aids particle suspension, air dispersion and particle–bubble collision. Therefore, it is important to understand effect that different impeller designs have on hydrodynamics, small variations could enhance performance. The study of hydrodynamics is, however, complex task due nature systems, which are opa...

PepT1 and PepT2 are major facilitator superfamily (MFS) transporters that utilize a proton gradient to drive the uptake of di- and tri-peptides in the small intestine and kidney, respectively. They are the major routes by which we absorb dietary nitrogen and many orally administered drugs. Here, we present the crystal structure of PepT(So), a functionally similar prokaryotic homologue of the ma...